inmunoadmin

Deciphering SARS-CoV-2 evolution under antibody immune pressure. Fanchong Jian

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Trends Immunol. 2025 Mar 27:S1471-4906(25)00076-6. doi: 10.1016/j.it.2025.03.002. Online ahead of print. ABSTRACT The ongoing evolution of SARS-CoV-2 poses significant challenges to existing neutralizing antibodies and vaccines through immune escape mutations. By leveraging genomic surveillance and antibody deep mutational scanning (DMS) data, Raharinirina and colleagues developed a computational framework to elucidate region-specific SARS-CoV-2 variant dynamics and … Read more

Airway epithelial cells as drivers of severe asthma pathogenesis. Del Dorscheid

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Mucosal Immunol. 2025 Mar 26:S1933-0219(25)00029-7. doi: 10.1016/j.mucimm.2025.03.003. Online ahead of print. ABSTRACT Our understanding of the airway epithelium’s role in driving asthma pathogenesis has evolved over time. From being regarded primarily as a physical barrier that could be damaged via inflammation, the epithelium is now known to actively contribute to asthma development through interactions with … Read more

The immunological processes behind aquaporin 4-antibody seropositive neuromyelitis optica spectrum disorders. Monika Bradl

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Semin Immunol. 2025 Mar 27;78:101945. doi: 10.1016/j.smim.2025.101945. Online ahead of print. ABSTRACT Ever since the discovery of pathogenic aquaporin 4-specific antibodies in the serum of patients with neuromyelitis optica spectrum disorders current knowledge about clinical observations and diagnosis, and about the underlying pathology and resulting therapies have been put forward in excellent reviews and primary … Read more

ERAP1-dependent extreme antigen processing efficacy can govern MHC class I expression hierarchy

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J Immunol. 2025 Mar 27:vkaf013. doi: 10.1093/jimmun/vkaf013. Online ahead of print. ABSTRACT Peptide presentation by major histocompatibility complex (MHC) class I molecules enables CD8+ T lymphocytes to monitor the intracellular proteome of tissue cells. CD8+ T cell priming and acquisition of effector functions is affected by cognate peptide-MHC-I complex density on the cell surface, which … Read more

Transcriptional and chromatin accessibility landscapes of hematopoiesis in a mouse model of breast cancer

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J Immunol. 2025 Mar 27:vkaf026. doi: 10.1093/jimmun/vkaf026. Online ahead of print. ABSTRACT Increased myeloid lineage production, termed myeloid skewing, leading to decreased tumor immunity, is a hallmark of aberrant hematopoiesis associated with cancer. It is believed that myeloid skewing may occur at the hematopoietic stem and progenitor cells (HSPCs) level to elicit hematopoietic changes. However, … Read more

DOCK2 Deficiency and GATA2 Haploinsufficiency Can Underlie Critical Coronavirus Disease 2019 (COVID-19) Pneumonia

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J Clin Immunol. 2025 Mar 28;45(1):85. doi: 10.1007/s10875-025-01877-z. ABSTRACT The life-threatening coronavirus disease 2019 (COVID-19) affects about 1 in 1,000 healthy people under 50 without underlying conditions. Among patients with critical COVID-19 pneumonia, rare germline variants at genes controlling type I IFN immunity have been reported in up to 5% of patients. Causal etiologies in … Read more

Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases

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Curr Opin Immunol. 2025 Mar 25;94:102552. doi: 10.1016/j.coi.2025.102552. Online ahead of print. ABSTRACT Given the growing evidence linking microglia to the onset and progression of various neurodegenerative diseases, these brain-resident macrophages have emerged as a promising cell type for targeted therapeutic interventions. This review highlights recent studies that utilized innovative, microglia-focused strategies for the treatment … Read more

Hippo-YAP pathway regulates antimicrobial immune response in obscure puffer Takifugu obscurus

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J Immunol. 2025 Mar 26:vkaf011. doi: 10.1093/jimmun/vkaf011. Online ahead of print. ABSTRACT The Hippo signaling pathway plays an important role in regulating host immune responses. However, few studies have explored its role in fish. Therefore, this study aimed to investigate the mechanism by which the Hippo pathway regulates the expression of antimicrobial peptides (AMPs) in … Read more

Metabolic Adaptations Driving Innate Immune Memory: Mechanisms and Therapeutic Implications​Dan Hao on 26 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 26:qiaf037. doi: 10.1093/jleuko/qiaf037. Online ahead of print. ABSTRACT Immune memory is a hallmark of the adaptive immune system. However, recent research reveals that innate immune cells also retain memory of prior pathogen exposure that prompts enhanced responses to subsequent infections. This phenomenon is termed “innate immune memory” or “trained immunity.” … Read more

Eph receptors activate myeloid checkpoint receptor LILRB5 to support tumor development

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Cancer Immunol Res. 2025 Mar 27. doi: 10.1158/2326-6066.CIR-24-0737. Online ahead of print. ABSTRACT Immunosuppressive myeloid cells are critical obstacles to T cell-centered immune checkpoint blockade therapies, which have been successful in treating a fraction of cancer patients. How tumor cells interact with myeloid cells to regulate immune responses and tumor development is unclear. Here, we … Read more

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