inmunoadmin

Galectin-3 regulates erythropoiesis and enhances the immunoregulatory properties of CD71+ erythroid cells across developmental stages

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J Immunol. 2025 Mar 22:vkaf020. doi: 10.1093/jimmun/vkaf020. Online ahead of print. ABSTRACT Galectins are expressed by different immune and nonimmune cells with diverse immunomodulatory properties. However, their roles in erythropoiesis remain unknown. We investigated the expression of galectin genes in splenic CD71+ erythroid cells (CECs) from neonatal BALB/c mice at various developmental stages using bulk … Read more

High-salt diet drives depression-like behavior in mice by inducing IL-17A production

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J Immunol. 2025 Mar 22:vkaf019. doi: 10.1093/jimmun/vkaf019. Online ahead of print. ABSTRACT Major depression disorder is a common illness that severely limits psychosocial functioning, affects outcomes of other diseases, and diminishes the quality of life. High-salt diet (HSD) has long been closely associated with the occurrence and development of depression, but whether or how HSD … Read more

DHODH inhibition alters T cell metabolism limiting acute graft-versus-host disease while retaining graft-versus-leukemia response

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J Immunol. 2025 Mar 22:vkaf023. doi: 10.1093/jimmun/vkaf023. Online ahead of print. ABSTRACT Acute graft-versus-host disease (GVHD) is a donor T cell driven complication and the leading cause of non-relapse mortality in patients receiving an allogeneic hematopoietic cell transplantation (allo-HCT). Allogeneic donor T cells eradicate residual leukemia and prevent relapse via the graft-versus-leukemia (GVL) effect and … Read more

Can autoimmune disease be cured by deep CD19+ cell depletion?

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J Immunol. 2025 Mar 21:vkaf008. doi: 10.1093/jimmun/vkaf008. Online ahead of print. ABSTRACT Therapeutic B cell depletion with monoclonal antibodies targeting CD20 forced a rethink about the pathogenic role of B cells and plasma cells in autoimmune diseases; however, it was tempered by frequent clinical relapses or nonresponse to CD20-directed therapy. Here, we re-evaluate B cell … Read more

Zebrafish hif1β attenuates antiviral innate immunity by suppressing Irf7 transcriptional activity

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J Immunol. 2025 Mar 21:vkaf018. doi: 10.1093/jimmun/vkaf018. Online ahead of print. ABSTRACT HIF1β, which serves as a common binding partner of the aryl hydrocarbon receptor and hypoxia-inducible factor (HIF)-α subunits, plays a key role in 2 cellular signaling pathways: the aryl hydrocarbon receptor and HIF pathways. Whether HIF1β is involved in antiviral innate immunity remains … Read more

Distinct roles of PGE2 signaling via EP2 and EP4 in circulating pDCs: implications for immune modulation in the tumor microenvironment​Jorge Cuenca-Escalona on 21 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 21:qiaf034. doi: 10.1093/jleuko/qiaf034. Online ahead of print. ABSTRACT Dendritic cells (DCs) play a pivotal role in orchestrating adaptive immunity in response to environmental cues such as prostaglandin E2 (PGE2). Tumors are known to establish a microenvironment rich in PGE2. Tumor-derived PGE2 is regarded as mediator of regulatory features in DCs, … Read more

Epigenetic Regulation of CD8+ Effector T Cell Differentiation by PDCD5. [[{“value”:”Lixue Jin, Xin Zhang, Jingyi Wang, Yujia Wang, Ke Wang, Zhuolin Wang, Pingzhang Wang, Xiuyuan Sun, Jie Hao, Rong Jin, Dan Lu, Qing Ge”}]]

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In CD8+ T cells, PDCD5 is an activation-induced molecule that interacts with PRDM9, thereby promoting its nuclear translocation and facilitating the H3K4me3 modification of genes associated with effector differentiation. ABSTRACT Epigenetic modification plays a crucial role in establishing the transcriptional program that governs the differentiation of CD8+ effector T cells. However, the mechanisms by which … Read more

ICAM‐1 Is Overexpressed by Cancers and Negatively Impacts Antibody‐Based Therapies Including Antibody–Drug Conjugates. [[{“value”:”J. Bradford Kline, Luigi Grasso, Nicholas C. Nicolaides”}]]

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Tumor-produced ICAM-1 protein binds to IgG1 antibodies and suppresses their antibody-dependent cellular (ADCC) and complement-dependent (CDC) cytotoxicity against antigen-positive cells via reduced engagement with CD16a receptors on immune effector cells and C1q complement protein. This interaction also reduces antibody internalization that negatively affects antibody–drug conjugate cytotoxicity. ABSTRACT Humoral immunity utilizes antibodies and immune effector cells to … Read more

Foxp3+CD8+ regulatory T cells: bona fide Tregs with cytotoxic function. Shunqun Luo

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Trends Immunol. 2025 Mar 19:S1471-4906(25)00053-5. doi: 10.1016/j.it.2025.02.010. Online ahead of print. ABSTRACT Various mammalian CD8+ T cell subsets with regulatory properties are either formed through a thymus-dependent mechanism or induced under various experimental protocols and referred to as CD8+ regulatory T cells (Tregs). CD8+ Tregs maintain distinct functions in the presence of CD4+ Tregs. This … Read more

Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections. Luna Minute

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Trends Immunol. 2025 Mar 19:S1471-4906(25)00055-9. doi: 10.1016/j.it.2025.02.012. Online ahead of print. ABSTRACT The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies as a complementary tool in our fight against respiratory infections. These immunotherapies can activate a wide spectrum of immunological mechanisms, … Read more

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