inmunoadmin

CD209d/e are required for macrophage-mediated phagocytosis and activation during methicillin-resistant Staphylococcus aureus pulmonary host defense

by

J Immunol. 2025 Mar 18:vkae061. doi: 10.1093/jimmun/vkae061. Online ahead of print. ABSTRACT Staphylococcus aureus is a commensal and opportunist pathogen of the upper respiratory tract. The recognition of pathogen-associated molecular patterns through pattern-recognition receptors is crucial for eliminating microorganisms such as S. aureus. DC-SIGN (CD209) is a pattern-recognition receptor that binds to a broad range … Read more

Cathelicidin-related antimicrobial peptide (CRAMP) is toxic during neonatal murine influenza virus infection

by

J Immunol. 2025 Mar 18:vkae053. doi: 10.1093/jimmun/vkae053. Online ahead of print. ABSTRACT Respiratory viral infections are a major contributor to mortality in children under 5 years of age, and disproportionately affect preterm neonates. Previously, using our established 3-day-old neonatal murine model of influenza virus infection, we demonstrated that treatment of neonatal mice with intranasal Lactobacillus … Read more

A genetically modulated Toll-like receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome

by

J Immunol. 2025 Mar 18:vkaf006. doi: 10.1093/jimmun/vkaf006. Online ahead of print. ABSTRACT Dysregulated innate immune responses contribute to multisystem inflammatory syndrome in children (MIS-C), characterized by gastrointestinal, mucocutaneous, and/or cardiovascular injury occurring weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure. To investigate innate immune functions, we stimulated ex vivo peripheral blood cells from … Read more

Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities. Lucas Mendes-Monteiro

by

Trends Immunol. 2025 Mar 18:S1471-4906(25)00056-0. doi: 10.1016/j.it.2025.02.013. Online ahead of print. ABSTRACT IFN-γ is a pleiotropic antiviral cytokine that coordinates innate and adaptive immune responses and induces both immunostimulatory and immunosuppressive activities, limiting its use in the clinic. Due to its antiviral role, several viruses express proteins that bind IFN-γ, blocking its interaction with the … Read more

Deficiency of Adenosine Deaminase 2 Masquerading as Behçet’s Disease: Phenotypic Mimicry with HLA-B*51 Positivity

by

J Clin Immunol. 2025 Mar 17;45(1):83. doi: 10.1007/s10875-025-01876-0. ABSTRACT PURPOSE: Deficiency of adenosine deaminase 2 (DADA2) is a rare monogenic autoinflammatory disease resulting from biallelic loss-of-function mutations in ADA2 gene. It has variable clinical manifestations, some of which can mimic Behçet’s disease (BD). Herein, we present a family of three siblings diagnosed with DADA2, two … Read more

Diagnosis, Characteristics, and Outcome of Selective Anti-polysaccharide Antibody Deficiencies In A Retrospective Cohort of 55 Adult Patients

by

J Clin Immunol. 2025 Mar 17;45(1):82. doi: 10.1007/s10875-025-01874-2. ABSTRACT Selective anti-polysaccharide antibody deficiency (SPAD) predisposes to encapsulated bacterial infections. The diagnosis is challenging, and literature reports are scarce in adult patients, we therefore aim to describe the demographics, infectious complications, therapeutic strategies, and outcome of adult patients. We conducted a multicenter observational study involving 55 … Read more

Exploring the genetic mechanisms driving KIR diversification

by

J Immunol. 2025 Mar 17:vkae047. doi: 10.1093/jimmun/vkae047. Online ahead of print. ABSTRACT Killer cell immunoglobulin-like receptors (KIRs) are key modulators of natural killer cell activity, displaying either activating or inhibitory potential upon recognition of major histocompatibility complex (MHC) class I molecules. The genomic organization of KIR genes is complex, involving copy number variation and allelic … Read more

IL-2Rα is dispensable for murine B cell development and humoral response

by

J Immunol. 2025 Mar 17:vkae045. doi: 10.1093/jimmun/vkae045. Online ahead of print. ABSTRACT The cytokine IL-2 plays a pivotal role in the immune system, specifically in the proliferation of T, B, and NK cells. The alpha subunit of the IL-2 receptor, IL-2Rα (CD25), is known to regulate the expansion and differentiation of T lymphocytes. CD25 is … Read more

deneme bonusu veren siteler - canlı bahis siteleri - casino siteleri casino siteleri deneme bonusu veren siteler canlı casino siteleri cURL Hatası: OpenSSL SSL_connect: SSL_ERROR_SYSCALL in connection to lkl.dolarkurum.com:443