inmunoadmin

Decoding microglial functions in Alzheimer’s disease: insights from human models. Chandrika Rao

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Trends Immunol. 2025 Mar 19:S1471-4906(25)00054-7. doi: 10.1016/j.it.2025.02.011. Online ahead of print. ABSTRACT Microglia, key orchestrators of the brain’s immune responses, play a pivotal role in the progression of Alzheimer’s disease (AD). Emerging human models, including stem cell-derived microglia and cerebral organoids, are transforming our understanding of microglial contributions to AD pathology. In this review, we … Read more

Exacerbated endoplasmic reticulum stress transmitted by endometrial stromal cells alters the conditioning of tolerogenic dendritic cells affecting trophoblast migration

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J Immunol. 2025 Mar 20:vkae065. doi: 10.1093/jimmun/vkae065. Online ahead of print. ABSTRACT Endometrial stromal cells acquire a secretory profile associated with endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) related to the onset of a sterile inflammatory response essential for sustaining embryo implantation. However, exacerbated stromal ERS/UPR is associated with reproductive complications. Given the … Read more

Differential expression of S100A10 protein in leukocytes and its effects on monocyte emigration from bone marrow

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J Immunol. 2025 Mar 20:vkaf021. doi: 10.1093/jimmun/vkaf021. Online ahead of print. ABSTRACT Although the importance of the unique member of S100 EF-hand family, S100A10 in health and disease is well appreciated, a precise characterization of S100A10 expression still remains elusive. To this purpose, we generated a knock-in mouse line in which downstream of the coding … Read more

Early neutrophil responses are potential biomarkers to predict severe COVID-19 in adults​Ananya Singh on 20 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 20:qiaf035. doi: 10.1093/jleuko/qiaf035. Online ahead of print. ABSTRACT In the early COVID-19 pandemic, the strain on healthcare facilities highlighted the need for reliable biomarkers to predict progression to severe COVID-19. Neutrophils, the most abundant leukocytes in circulation, are early defenders against pathogens. In a Singaporean adult cohort, early neutrophil mediators … Read more

IL-7Rα signaling in regulatory T cells of adipose tissue is essential for systemic glucose homeostasis

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J Immunol. 2025 Mar 19:vkae064. doi: 10.1093/jimmun/vkae064. Online ahead of print. ABSTRACT Regulatory T cells (Tregs) mediate tissue homeostasis and repair. The function of the interleukin-7 receptor α (IL-7Rα) in nonlymphoid tissue Tregs is still unknown, although low expression of IL-7Rα is a widely accepted marker for Tregs. Here, we show that IL-33R (ST2)-expressing Tregs … Read more

Intrapulmonary-administered myeloid derived suppressor cells rescue mice from Pseudomonas aeruginosa infection and promote a regulatory/repair phenotype. Maëlys Born-Bony

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Mucosal Immunol. 2025 Mar 17:S1933-0219(25)00027-3. doi: 10.1016/j.mucimm.2025.03.001. Online ahead of print. ABSTRACT Pseudomonas aeruginosa (P.aeruginosa) is a pathogenic opportunistic bacterium, classified as a priority by the WHO for the research of new treatments. As this bacterium is harmful through the inflammation and tissue damage it causes, we investigated the role of Myeloid Derived Suppressor Cells … Read more

JAK Inhibitors and B Cell Function: A Comparative Study of Their Impact on Plasma Cell Differentiation, Cytokine Production, and Naïve B Cell Activation. [[{“value”:”Wenqi Huang, Charlotte de Vries, Ravi Kumar Sharma, Kittikorn Wangriatisak, Katerina Chatzidionysiou, Vivianne Malmström, Caroline Grönwall”}]]

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JAK inhibitors (baricitinib, tofacitinib, upadacitinib), except for filgotinib, significantly reduce plasmablast differentiation but only partly inhibit activation of naïve B cells and exert a more modest effect on TNF and IL-8 production. Unlike other JAK inhibitors, filgotinib selectively inhibits STAT5 phosphorylation without affecting STAT3 phosphorylation in response to IL-21. ABSTRACT B cells play a crucial … Read more

A Mouse Model for Generation of Gut Lamina Propria Plasma Cells Specific for a Deamidated Gluten Peptide. [[{“value”:”Runa I. Løberg, Alisa E. Dewan, Liv Kleppa, M. Fleur du Pré, Ludvig M. Sollid”}]]

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The 1E03 immunoglobulin knock-in mouse produces B cells reactive to deamidated gluten peptides (DGP). The transfer of DGP-specific B cells and immunization with a DGP-cholera toxin conjugate led to the formation of DGP-reactive small-intestinal lamina propria plasma cells and serum antibodies. This model enables studies of plasma cells associated with celiac disease. ABSTRACT Celiac disease … Read more

Cellular immune changes during severe antisense oligonucleotide-associated thrombocytopenia in a nonhuman primate model

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J Immunol. 2025 Mar 18:vkae055. doi: 10.1093/jimmun/vkae055. Online ahead of print. ABSTRACT Antisense oligonucleotides (ASOs) are a new class of single-stranded DNA-based drugs that hold great therapeutic potential. A low incidence of severe, dose-dependent, and reversible thrombocytopenia (TCP) (platelets < 50 K/μl) has been reported in nonhuman primate (NHP) populations, following treatment of monkeys with … Read more

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