inmunoadmin

High fat diet feeding impairs neutrophil phagocytosis, bacterial killing, and neutrophil-induced hematopoietic regeneration

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J Immunol. 2025 Mar 17:vkaf024. doi: 10.1093/jimmun/vkaf024. Online ahead of print. ABSTRACT The prevalence of obesity and metabolic diseases have risen significantly over the past decades. Chronic inflammation in obesity is a link between obesity and secondary disease. While macrophages and monocytes are known to contribute to metabolic disease risk during diet exposure, little is … Read more

Hematopoietic MyD88 orchestrates the control of gut colonization by segmented filamentous bacteria. Marie Cherrier

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Mucosal Immunol. 2025 Mar 14:S1933-0219(25)00028-5. doi: 10.1016/j.mucimm.2025.03.002. Online ahead of print. ABSTRACT Host-microbiota cooperation is critical for successful intestinal homeostasis. The commensal segmented filamentous bacteria (SFB) are crucial for orchestrating the post-natal maturation of the host gut immune system and establishing a healthy state of physiological inflammation, which largely depends on their intimate attachment to … Read more

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): Insights into pathogenesis and biomarkers of prognosis. Jane Andersen

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Semin Immunol. 2025 Mar 14;78:101944. doi: 10.1016/j.smim.2025.101944. Online ahead of print. ABSTRACT MOG antibody-associated disease (MOGAD), an inflammatory demyelinating pathology, is typically associated with the clinical phenotypes acute disseminated encephalomyelitis (ADEM), optic neuritis (ON), or transverse myelitis (TM). The mainstay of diagnosis is detection of antibodies targeting oligodendrocyte-expressed MOG (MOG-IgG). MOG-IgG-mediated demyelination occurs via complement-dependent … Read more

Sex differences in age-related cardiac and splenic S100A9 and NLRP3 expression​Kathleen Pappritz on 14 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 15:qiaf031. doi: 10.1093/jleuko/qiaf031. Online ahead of print. ABSTRACT Age is an important risk factor for cardiovascular diseases (CVD) and associated with a systemic, low-grade inflammation, so called “inflammaging”. We aimed to investigate the impact of age and sex on the inflammatory markers S100A9 and components of the NLRP3 inflammasome at … Read more

Afucosylated broadly neutralising antibodies targeting HIV envelope elicit enhanced NK cell-mediated cytotoxicity against HIV-infected CD4+ T cell and macrophage targets​Olivia Wilhelm on 14 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 15:qiaf033. doi: 10.1093/jleuko/qiaf033. Online ahead of print. ABSTRACT Enhancement of antibody-dependent cellular cytotoxicity (ADCC) is a promising adjunct approach to achieve HIV control in the absence of antiretroviral therapy but requires the development of potent ADCC-eliciting antibodies which can recognise diverse HIV-infected cell types. A panel of broadly neutralising antibodies … Read more

Differential immune responses behind different celiac disease manifestations. Esko Kemppainen

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Semin Immunol. 2025 Mar 13;78:101941. doi: 10.1016/j.smim.2025.101941. Online ahead of print. ABSTRACT In celiac disease (CeD), dietary gluten serves as the driver for a comparatively well characterized small bowel mucosal immune response that generally results in small bowel mucosal villous atrophy and crypt hyperplasia along with a disease-specific transglutaminase 2 (TG2) targeting autoantibody response. Individuals … Read more

Sustained activation induced cytidine deaminase (AID) expression in B cells following Plasmodium falciparum malaria infection in Kenyan children

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J Immunol. 2025 Mar 14:vkaf005. doi: 10.1093/jimmun/vkaf005. Online ahead of print. ABSTRACT Burkitt lymphoma (BL) is characterized by elevated levels of the enzyme activation-induced cytidine deaminase (AID), an enzyme critical for MYC translocation that is the hallmark of BL. Both EBV and Plasmodium falciparum malaria are cofactors in the etiology of BL. However, how these … Read more

HLA-E/peptide complexes differentially interact with NKG2A/CD94 and T cell receptors

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J Immunol. 2025 Mar 14:vkae068. doi: 10.1093/jimmun/vkae068. Online ahead of print. ABSTRACT The virtually monomorphic antigen presentation molecule HLA-E can present self- and non-self peptides to the NKG2A/CD94 co-receptor inhibitory complex expressed on natural killer (NK) cells and to T cell receptors (TCRs) expressed on T cells. HLA-E presents self-peptides to NKG2A/CD94 to regulate tissue … Read more

There and back again: PD-L1 Positivity as a Biomarker for Immune Checkpoint Blockade in Urothelial Carcinoma

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Cancer Immunol Res. 2025 Mar 14:OF1-OF2. doi: 10.1158/2326-6066.CIR-25-0202. Online ahead of print. ABSTRACT Biomarkers of responsiveness to immune checkpoint blockade (ICB) are heavily sought given the breadth and depth of the use of ICB in cancer. PD-L1 expression was among the first biomarkers identified, but multiple factors have precluded more widespread use. In this issue, … Read more

CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment

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Cancer Immunol Res. 2025 Mar 14:OF1-OF20. doi: 10.1158/2326-6066.CIR-24-0151. Online ahead of print. ABSTRACT Immunotherapies have had unprecedented success in the treatment of multiple cancer types, albeit with variable response rates. Unraveling the complex network of immune cells within the tumor microenvironment (TME) may provide additional insights to enhance antitumor immunity and improve clinical response. Many … Read more

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