inmunoadmin

Complement factor H is a central regulator of the complement system and thus a target for therapeutic intervention. In this review, we provide an overview of past and current factor H-based therapeutic concepts and modalities to treat complement-mediated diseases. ABSTRACT The complement system is a key component of innate immunity, modulating immunological processes to maintain … Read more

Immunological disturbances such as persistent activation of immune cells and reduced cytotoxicity by natural killer (NK) cells are reported as key aspects in post-COVID-19 condition (PCC). Our findings provide new evidence of altered passive and TRPM3-mediated Ca2+ influx, significantly impacting cytoplasmic and mitochondrial Ca2+ mobilization in PCC. ABSTRACT According to the World Health Organization (WHO), … Read more

This review examines how a high-salt diet disrupts gut microbiota composition, impairs intestinal barrier integrity, and modulates macrophage function, with a focus on their interconnection along the gut-liver axis. It highlights key methodological challenges, summarizes current mechanistic understanding, and identifies critical gaps for future research. ABSTRACT The Global North is increasingly exposed to a Western … Read more

Pam3CSK4 amplifies aPL-induced monocyte activation. This results in thromboinflammatory activation that may contribute to APS-related vascular pathology. ABSTRACT Antiphospholipid antibodies (aPL) are drivers of inflammation and thrombosis in antiphospholipid syndrome (APS). However, the molecular mechanisms underlying infection-induced exacerbation of APS remain incompletely understood. To identify novel pathways contributing to the pro-inflammatory and pro-coagulant activation of … Read more