inmunoadmin

IL-1β signaling as a molecular arbiter of stem cell plasticity: orchestrating the niches of repair, fibrosis, and cancer. Sua Yu

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Semin Immunol. 2026 Jul 24;83:102050. doi: 10.1016/j.smim.2026.102050. Online ahead of print. ABSTRACT Interleukin-1β (IL-1β) has long been characterized as a foundational mediator of innate immunity, yet this designation captures only a fraction of its biological significance. A growing body of evidence now positions IL-1β as a molecular arbiter of tissue restoration – a context-sensitive instructor … Read more

Periductal Fibroblast Density Defines Lymphocyte Exclusion via a CD44-Dependent Stromal Checkpoint in Pancreatic Cancer

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Cancer Immunol Res. 2026 Jul 24. doi: 10.1158/2326-6066.CIR-25-1481. Online ahead of print. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) exhibits dense fibrosis and immune exclusion. While fibrosis has been studied globally and at the region-of-interest level, its impact on stromal-ductal architecture and immune cell localization remains unknown. Here, we establish cancer-associated fibroblast (CAF)-stratified ductal spatial architecture as … Read more

Phylogenetic analysis of amino acid sequences indicates a central role of transmembrane domain structural elements in MHC class II function

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J Immunol. 2026 Jul 10;215(7):vkag192. doi: 10.1093/jimmun/vkag192. ABSTRACT Human leukocyte antigen class II genes are highly polymorphic. This raises the question of how polymorphisms are distributed across the entirety of the class II molecule and how this distribution affects function. We performed a comprehensive analysis of amino acid variability across the entire class II molecule, … Read more

Cure for psoriasis – a prospective outlook

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Curr Opin Immunol. 2026 Jul 23;102:102820. doi: 10.1016/j.coi.2026.102820. Online ahead of print. ABSTRACT Once considered incurable, psoriasis is now being re-evaluated in light of sustained, drug-free remissions, prompting a redefinition of ‘cure’ as long-term/drug-free remission. Psoriatic disease is primarily driven by dysregulation of the interleukin-23 (IL-23)/IL-17 axis, and the survival of tissue-resident memory T cells … Read more

Single-cell RNA sequencing reveals intrinsic and microbiota-associated sex differences in murine lung. Alexandra Melton

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Mucosal Immunol. 2026 Jul 23:100389. doi: 10.1016/j.mucimm.2026.100389. Online ahead of print. ABSTRACT Sex-based differences in respiratory disease outcomes are well recognized. However, the underlying immunological mechanisms driving this dimorphism remain incompletely understood. While sex hormones influence immune cell development and function, the role of commensal microbes in shaping sex-specific lung immunity has not been explored. … Read more

TLR-Mediated Calcium Signaling Regulates Killing Capacity of Expanded NK Cells: Challenges for Potential AML Immunotherapy​Vojtěch Graman on 23 de July de 2026 at 10:00

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J Leukoc Biol. 2026 Jul 23:qiag092. doi: 10.1093/jleuko/qiag092. Online ahead of print. ABSTRACT Natural killer (NK) cells are central to cancer immunosurveillance and immunotherapy. Their ability to engage in killing is critical for efficient target elimination and depends on tightly regulated Ca2+ signaling controlling granzyme degranulation. TLR engagement has been linked to Ca2+ signaling in … Read more

TLR-Mediated Calcium Signaling Regulates Killing Capacity of Expanded NK Cells: Challenges for Potential AML Immunotherapy​Vojtěch Graman on 23 de July de 2026 at 10:00

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J Leukoc Biol. 2026 Jul 23:qiag092. doi: 10.1093/jleuko/qiag092. Online ahead of print. ABSTRACT Natural killer (NK) cells are central to cancer immunosurveillance and immunotherapy. Their ability to engage in killing is critical for efficient target elimination and depends on tightly regulated Ca2+ signaling controlling granzyme degranulation. TLR engagement has been linked to Ca2+ signaling in … Read more

Kaempferol’s potential in targeting IL-17-mediated inflammatory pathways for colorectal cancer treatment

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J Immunol. 2026 Jul 10;215(7):vkag176. doi: 10.1093/jimmun/vkag176. ABSTRACT Colorectal cancer (CRC) is a leading malignancy with limited treatment options at advanced stages. Interleukin (IL)-17 signaling promotes tumor progression and immune evasion. Kaempferol, a natural flavonol, has anti-inflammatory and antitumor effects, but its role in modulating IL-17 pathways in CRC is unclear. We used an immunocompetent … Read more

Gammaherpesvirus infection impairs lung fibrosis resolution through PD-L1+ fibroblasts and PD-1+ CD8+ T cell interaction. Laura Kempen

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Mucosal Immunol. 2026 Jul 22:100388. doi: 10.1016/j.mucimm.2026.100388. Online ahead of print. ABSTRACT Pulmonary fibrosis is a complex disease with poorly understood, multifactorial triggers. Gammaherpesviruses (γHVs), including Epstein-Barr virus in humans and Murid herpesvirus 4 (MuHV-4) in mice, have been linked to pulmonary fibrosis exacerbation, although the underlying mechanisms remain unclear. This study explores how γHV … Read more

Complement Factor H‐Based Therapeutics: A Comprehensive Overview. [[{“value”:”Sebastiaan M. W. R. Hamers, Emmy J. Buter, Richard B. Pouw”}]]

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Complement factor H is a central regulator of the complement system and thus a target for therapeutic intervention. In this review, we provide an overview of past and current factor H-based therapeutic concepts and modalities to treat complement-mediated diseases. ABSTRACT The complement system is a key component of innate immunity, modulating immunological processes to maintain … Read more

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