The discovery and roles of type 2 innate lymphoid cells
J Immunol. 2026 Jul 10;215(7):vkag104. doi: 10.1093/jimmun/vkag104. NO ABSTRACT PMID:42437361 | DOI:10.1093/jimmun/vkag104
inmunoadmin
Long-term survivors of melanoma after anti-PD-1 therapy demonstrate on-treatment increase in abundance of 4-1BB+ CD4 T cells in blood
J Immunol. 2026 Jul 10;215(7):vkag171. doi: 10.1093/jimmun/vkag171. ABSTRACT Anti-PD-1 monotherapy has shown a significant survival benefit for patients with advanced-stage melanoma. In this study, we explored whether long-term clinical benefit is determined by abundance or changes in such abundances of CD4 and CD8 T-cell subsets in blood. Peripheral blood mononuclear cells from 58 patients with … Read more
Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis
J Immunol. 2026 Jul 10;215(7):vkag163. doi: 10.1093/jimmun/vkag163. ABSTRACT Success of B cell depletion therapy in multiple sclerosis (MS), an immune-mediated demyelinating disease of the central nervous system, places B cells and their functions center stage in efforts to fully understand pathogenesis. Historically, MS animal models of experimental autoimmune encephalomyelitis have featured B cell-independent disease driven … Read more
CD22 is upregulated and displays suppressive properties on CD4+ T cells upon a persistent virus infection
J Immunol. 2026 Jul 10;215(7):vkag183. doi: 10.1093/jimmun/vkag183. ABSTRACT Chronic viral infections evade or suppress host immunity, posing risks to global human health. However, the underlying mechanisms of viral immune suppression are incompletely defined. Previously, we have demonstrated that sphingosine kinase 2 (SphK2) represses CD4+ T-cell immunity during lymphocytic choriomeningitis virus (LCMV) Clone 13 (Cl 13) … Read more
Mapping antibody sequences and effector functions across spatial niches
Curr Opin Immunol. 2026 Jul 10;102:102816. doi: 10.1016/j.coi.2026.102816. Online ahead of print. ABSTRACT Antibodies are fundamental to human health but can also drive pathology. Each antibody has a molecular specificity, encoded by their clonally heritable B cell receptor (BCR). Recent advances in spatial transcriptomics coupled with repertoire sequencing have enabled capturing antibody-secreting cells (ASCs) and … Read more
Gut segmented filamentous Bacteria impedes growth of B16F10 subcutaneous tumors via modulating T cell function. Hirohito Abo
Mucosal Immunol. 2026 Jul 10:100382. doi: 10.1016/j.mucimm.2026.100382. Online ahead of print. ABSTRACT Intestinal microbiota composition influences innate and adaptive immunity, both within and beyond the intestine. A prominent example of the latter is segmented filamentous bacteria (SFB), whose gut colonization reprograms alveolar macrophages (AM) and systemically shapes T cell polarity. We hypothesized that these impacts … Read more
rhIL-32γ Facilitates Macrophage Phagocytosis of Streptococcus pneumoniae by Activating NF-κB-Soluble Epoxide Hydrolase PathwayLongying Liang on 10 de July de 2026 at 10:00
J Leukoc Biol. 2026 Jul 10:qiag093. doi: 10.1093/jleuko/qiag093. Online ahead of print. ABSTRACT Interleukin (IL)-32 is recognized as a potent proinflammatory mediator in various infectious contexts, however, its precise contribution to host defense against Streptococcus pneumoniae (S. pneumoniae) remains to be fully elucidated. This study demonstrates that S. pneumoniae challenge robustly upregulates IL-32 expression in … Read more
Editor’s Note on ‘Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9’ on 10 de July de 2026 at 10:00
J Leukoc Biol. 2026 Jul 3;118(7):qiag070. doi: 10.1093/jleuko/qiag070. NO ABSTRACT PMID:42430651 | DOI:10.1093/jleuko/qiag070
DLL4+ Neutrophils Induce Alveolar Macrophages to Cause ADAM-17-mediated Endothelial Barrier Disruption and the Increase of ICAM1hiCXCR1lo Neutrophils in SepsisHui Jin on 10 de July de 2026 at 10:00
J Leukoc Biol. 2026 Jul 10:qiag097. doi: 10.1093/jleuko/qiag097. Online ahead of print. ABSTRACT Sepsis remains a leading cause of death. Reverse migrated (RM) neutrophils, characterized as ICAM1hiCXCR1lo, have been recognized as a key driver of systemic inflammation and organ injury in sepsis. We have recently discovered a distinct DLL4+ subset of neutrophils that accumulate in … Read more
Rhinovirus Infection May Contribute to Esophageal Inflammation in Eosinophilic EsophagitisPaul S Fichtinger on 10 de July de 2026 at 10:00
J Leukoc Biol. 2026 Jul 10:qiag095. doi: 10.1093/jleuko/qiag095. Online ahead of print. ABSTRACT Eosinophil esophagitis (EoE) shares many epidemiologic and pathophysiologic characteristics with other allergic diseases, especially allergic asthma. Since rhinovirus (RV) infection is known to contribute to inflammation in allergic asthma, we sought to investigate whether RV might also contribute to esophageal inflammation in … Read more