inmunoadmin J Immunol. 2026 Jul 10;215(7):vkag162. doi: 10.1093/jimmun/vkag162. ABSTRACT Our group discovered a mutation in a French-Canadian family causing a severe and early-onset form of emphysema. The heterozygote mutation located in the PTPN6 gene causes an alanine to threonine switch near the catalytic site of SHP-1, leading to a reduction of its enzymatic activity. In this … Read more
J Clin Immunol. 2026 Jul 11. doi: 10.1007/s10875-026-02051-9. Online ahead of print. ABSTRACT NFKB2 encodes the precursor p100 which undergoes processing to generate the mature NF-κB2 transcription factor subunit p52. Most of the known pathogenic NFKB2 variants render p100 un-processable and are typically linked to immunodeficiency disorders with antibody deficiency, susceptibility to infections and often … Read more
Curr Opin Immunol. 2026 Jul 9;102:102815. doi: 10.1016/j.coi.2026.102815. Online ahead of print. ABSTRACT Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by sicca symptoms, fatigue, multiorgan involvement, and an increased risk of B-cell lymphoma. Accumulating evidence over the past decades indicates that epithelial cells are not passive targets but active drivers of disease. … Read more
Cancer Immunol Res. 2026 Jul 9. doi: 10.1158/2326-6066.CIR-25-0777. Online ahead of print. ABSTRACT Intratumoral signaling via the cytosolic double-stranded RNA (dsRNA) receptors RIG-I and MDA-5 enhance antitumor immunity and can overcome resistance to cancer immunotherapy. Although BET proteins are established epigenetic drivers of immune escape mechanisms, their role in regulating RIG-I-like receptor (RLR) signaling remains … Read more
J Leukoc Biol. 2026 Jul 3;118(7):qiag085. doi: 10.1093/jleuko/qiag085. ABSTRACT As tissue-resident innate immune cells of the central nervous system, microglia are capable of acquiring innate immune memory-a persistent state of functional reprogramming triggered by prior stimuli. This memory typically manifests as 3 distinct phenotypes: trained immunity, immune tolerance, and immune exhaustion. In this review, we … Read more
J Clin Immunol. 2026 Jul 9. doi: 10.1007/s10875-026-02046-6. Online ahead of print. ABSTRACT PURPOSE: Hyper-IgM syndromes (HIGM) are primary immunodeficiencies characterized by defective class-switch recombination (CSR) and impaired humoral immunity. While genetic causes such as CD40L and AICDA mutations are well established, a detailed comparison of B cell maturation dynamics across HIGM subtypes remains limited. … Read more
J Immunol. 2026 Jun 7;215(6):vkag155. doi: 10.1093/jimmun/vkag155. ABSTRACT Staphylococcus aureus (SA), the most common cystic fibrosis (CF) respiratory pathogen, is uniquely capable of producing superantigen (SAg) exotoxins, which are recognized as the most potent activators of the immune system and inducers of inflammation. Although a high frequency of CF SA isolates can produce SA-SAgs, their … Read more
J Immunol. 2026 Jun 7;215(6):vkag140. doi: 10.1093/jimmun/vkag140. ABSTRACT Acute lung injury (ALI) is a fulminant respiratory failure syndrome with no targeted therapy. We show that Inhba is sharply upregulated in the damaged lung tissue of mice and in BEAS-2B cells, and its abundance tracks with cytokine storm and reactive oxygen species (ROS). Mechanistically, AKT activation … Read more
J Immunol. 2026 Jun 7;215(6):vkag164. doi: 10.1093/jimmun/vkag164. ABSTRACT Memory CD8 T cells respond rapidly upon antigen re-encounter and are considered advantageous for protective immunity. However, they undergo a swift decline under chronic antigen stimulation. In this study, we found that memory CD8 T cells’ heightened activation sensitivity promotes terminal differentiation and impairs the formation of … Read more
Mucosal Immunol. 2026 Jul 8:100381. doi: 10.1016/j.mucimm.2026.100381. Online ahead of print. ABSTRACT Licensure of influenza vaccines relies on serum hemagglutination inhibition (HAI) titers, a correlate of protection (CoP) that was developed more than 50 years ago and which is only poorly predictive of protection. This is especially true of immunity induced by intranasal live attenuated … Read more
