inmunoadmin – Page 31

GATA2 deficiency: enhancer deregulation, immune surveillance failure, and clonal evolution

16 de July de 2026 by inmunoadmin

Curr Opin Immunol. 2026 Jul 15;102:102817. doi: 10.1016/j.coi.2026.102817. Online ahead of print. ABSTRACT Germline mutations in GATA2 cause a syndromic inborn error of immunity characterized by cytopenia, infections, immune dysregulation, and a marked predisposition to myelodysplastic syndrome and acute myeloid leukemia. Initially defined by the DCML phenotype-dendritic cell, monocyte, B- and NK-cell deficiency-GATA2 deficiency is … Read more

Systemic and lung-resident memory elicited by OC43 coronavirus infection in mice

16 de July de 2026 by inmunoadmin

J Immunol. 2026 Jul 10;215(7):vkag182. doi: 10.1093/jimmun/vkag182. ABSTRACT Endemic coronaviruses circulate seasonally and, while typically mild, can produce robust inflammation and severe pneumonia. Immunological memory to coronaviruses can be cross-reactive for multiple coronaviruses including OC43 and SARS-CoV-2. In this study, we used mouse models to investigate immune responses elicited by pulmonary infection with OC43. OC43 … Read more

A novel Vδ1 engager targeting CD19 enhances human Vδ1 γδ T cell responses against CLL and CD19+ hematological malignancies

16 de July de 2026 by inmunoadmin

J Immunol. 2026 Jul 10;215(7):vkag167. doi: 10.1093/jimmun/vkag167. ABSTRACT γδ T cells are associated with favorable outcomes in many cancers likely through a mechanism of stress-directed cytotoxicity and antitumor cytokine production. Vδ1 γδ T cells are especially promising for immunotherapy due to their broad stress recognition and resistance to activation-induced cell death. Here, we generate a … Read more

Tim-3 Sustains Tumor Treg Stability and Function, Limiting Checkpoint Blockade Therapy Efficacy

15 de July de 2026 by inmunoadmin

Cancer Immunol Res. 2026 Jul 15. doi: 10.1158/2326-6066.CIR-25-0687. Online ahead of print. ABSTRACT Regulatory T cells (Treg) act as a powerful barrier to effective antitumor immunity. Although manipulating Treg is a promising anticancer strategy, doing so while sparing general immune tolerance has been a challenge. Identifying factors specifically expressed in tumor-infiltrating Treg is therefore important … Read more

HS1 loss drives cytoskeletal dysregulation and reduces sensitivity to BTK inhibition in chronic lymphocytic leukemiaLuca Russo on 15 de July de 2026 at 10:00

15 de July de 2026 by inmunoadmin

J Leukoc Biol. 2026 Jul 15:qiag099. doi: 10.1093/jleuko/qiag099. Online ahead of print. ABSTRACT Chronic lymphocytic leukemia (CLL) is a B-cell malignancy driven by aberrant signaling and microenvironmental support. Cytoskeletal remodeling contributes to these mechanisms, where the hematopoietic protein HS1 appears to play a key role. Thus, we generated C57BL/6 HS1 knockout (KO) mice to assess … Read more

Biomaterial-guided macrophage modulation: Therapeutic engineering of immune microenvironments. Jordan Popov

15 de July de 2026 by inmunoadmin

Trends Immunol. 2026 Jul 14:S1471-4906(26)00163-8. doi: 10.1016/j.it.2026.06.007. Online ahead of print. ABSTRACT Macrophages are central regulators of immunity, tissue homeostasis, and repair, whose plasticity enables them to integrate cues from their local microenvironment. Dysregulated macrophages contribute to chronic inflammation, fibrosis, impaired wound healing, and tumor progression. Biomaterials enable the modulation of macrophages through localized delivery … Read more

A Patient-Derived Screen Identifies HDAC Inhibitors as Enhancers of Phagocytosis and Potent Immunotherapy Partners

14 de July de 2026 by inmunoadmin

Cancer Immunol Res. 2026 Jul 14. doi: 10.1158/2326-6066.CIR-25-0506. Online ahead of print. ABSTRACT Glioblastoma multiforme (GBM) is a lethal brain tumor with limited treatment options. Tumor-associated macrophages and microglia (TAMs) drive immune suppression and tumor progression, making them a key therapeutic target for GBM. Enhancing TAM phagocytosis in GBM has shown promise, particularly with innate … Read more

Whole-body irradiation causes long-term impairments in the maintenance and function of naïve CD4 T cells specific for self- and non-self-antigens

14 de July de 2026 by inmunoadmin

J Immunol. 2026 Jul 10;215(7):vkag174. doi: 10.1093/jimmun/vkag174. ABSTRACT Whole-body irradiation (WBI) consistently induces radiation-associated lymphopenia, a complication linked to poor prognosis and reduced overall survival. Understanding the quantitative and qualitative changes in naïve CD4 T cells after WBI is critical because these cells play key roles in both host defense and the propagation of autoimmunity. … Read more

Early postnatal eosinophil expansion associates with gut microbial-metabolic features and type 2 immunity in preterm infants. Huiyu Chen

14 de July de 2026 by inmunoadmin

Mucosal Immunol. 2026 Jul 13:100383. doi: 10.1016/j.mucimm.2026.100383. Online ahead of print. ABSTRACT BACKGROUND: Early postnatal gut colonization, microbial metabolite production, and immune maturation proceed in parallel. Although disruption has been linked to later allergic disease, cellular immune patterns remain insufficiently defined. Very and extremely preterm infants frequently develop eosinophilia, providing a setting to relate eosinophil … Read more

Evaluation of T-cell Clonality by T-cell Constant β Chain (TRBC)1 and TRBC2 Expression Flow Cytometry in Hypereosinophilic SyndromeAlejandra Sánchez-Santos on 13 de July de 2026 at 10:00

13 de July de 2026 by inmunoadmin

J Leukoc Biol. 2026 Jul 13:qiag094. doi: 10.1093/jleuko/qiag094. Online ahead of print. ABSTRACT Hypereosinophilic syndrome (HES) is a rare hematopoietic disorder characterized by persistently elevated hypereosinophilia (HE) in peripheral blood and tissues, leading to multiorgan damage. HES can be classified into different subtypes based on diagnostic criteria and clinical characteristics: primary (neoplastic), secondary (reactive), idiopathic … Read more