inmunoadmin J Immunol. 2026 Jun 7;215(6):vkag115. doi: 10.1093/jimmun/vkag115. ABSTRACT Inhalation of house dust mite-derived allergens is a major factor leading to the development of asthma both in children and adults. Allergens stimulate Ca2+-dependent pro-inflammatory cytokine and chemokine gene expression through the opening of ORAI1 Ca2+ channels in the surface membrane of various immune cell-types within the … Read more
Curr Opin Immunol. 2026 Jul 6;101:102813. doi: 10.1016/j.coi.2026.102813. Online ahead of print. ABSTRACT Ion channels are classically regarded as regulators of electrical excitability, but their role in immune activation and barrier homeostasis extends far beyond global transmembrane ion flux. This functional diversity is, among other things, the result of noncanonical signaling pathways. In this review, … Read more
J Clin Immunol. 2026 Jul 6;46(1):73. doi: 10.1007/s10875-026-02048-4. ABSTRACT Lipopolysaccharide-responsive beige-like anchor protein (LRBA) deficiency is a primary inborn error of immunity characterized by immune dysregulation and frequently associated with autoimmune connective tissue manifestations. We describe an adult woman diagnosed with rheumatoid arthritis who was subsequently found to have LRBA deficiency based on genetic testing … Read more
Mucosal Immunol. 2026 Jul 5:100376. doi: 10.1016/j.mucimm.2026.100376. Online ahead of print. ABSTRACT A central challenge faced by the immune system is not simply detecting microbes but determining how to respond to them. In the intestine, where commensals and pathogens coexist, this decision is neither binary nor dictated by a single receptor. Instead, it emerges from … Read more
J Immunol. 2026 Jun 7;215(6):vkag161. doi: 10.1093/jimmun/vkag161. ABSTRACT Neurotrophic keratitis (NK) arises when trigeminal sensory dysfunction reduces corneal sensation and compromises epithelial maintenance. Herpes simplex virus type 1 (HSV-1) establishes latency in the trigeminal ganglion (TG) and is a common trigger of acquired NK, yet the host programs that determine whether inflamed ganglia recover or … Read more
Mucosal Immunol. 2026 Jul 4:100377. doi: 10.1016/j.mucimm.2026.100377. Online ahead of print. ABSTRACT Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system associated with alterations in gut commensals, including Akkermansia muciniphila (A. muciniphila). However, its role in MS remains unclear. Here, we report elevated serum lipopolysaccharide (LPS) and anti-LPS IgG levels in patients … Read more
J Clin Immunol. 2026 Jul 4. doi: 10.1007/s10875-026-02050-w. Online ahead of print. ABSTRACT PURPOSE: Thymic epithelial tumors (TETs) are associated with Good Syndrome (GS), a secondary immunodeficiency characterized by hypogammaglobulinemia, B-cell lymphopenia, and recurrent infections. This study investigated the immunological profile of TET patients to identify immune alterations associated with GS, independently of autoimmune diseases … Read more
J Immunol. 2026 Jun 7;215(6):vkag131. doi: 10.1093/jimmun/vkag131. ABSTRACT Type I interferons (IFNs) are central antiviral cytokines in vertebrates, yet the mechanisms underlying their functional diversification in early vertebrates remain unclear. Teleost fish, whose IFN repertoires expanded through whole-genome duplication, provide a powerful model to address this question. Here, we systematically characterize grass carp (Ctenopharyngodon idella) … Read more
Cancer Immunol Res. 2026 Jul 3. doi: 10.1158/2326-6066.CIR-26-0009. Online ahead of print. ABSTRACT Tumors remodel extracellular matrix (ECM) and glycosylation, yielding epitopes with restricted or limited detectability in normal adult tissues. Here, we evaluated the O-glycosylated IIICS domain of fibronectin (Tn-FN) as a chimeric antigen receptor (CAR) T cell target. FDC6-BBζ CAR T cells recognizing … Read more
Cancer Immunol Res. 2026 Jul 3. doi: 10.1158/2326-6066.CIR-25-0794. Online ahead of print. ABSTRACT While mutant-specific KRAS inhibitors are approved to treat cancer, a deeper understanding of intratumoral changes driven specifically by KRAS inhibition is needed to maximize therapeutic responses. Here, we used single-cell RNA-seq, flow cytometry, and spatial transcriptomics to distinguish mechanisms of tumor control … Read more
