inmunoadmin

Integrin β7 sustains ileal humoral immunity and microbial biogeography during chronic TNF-driven ileitis. Zining Shen

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Mucosal Immunol. 2026 Jul 8:100378. doi: 10.1016/j.mucimm.2026.100378. Online ahead of print. ABSTRACT Integrin α4β7 directs lymphocyte trafficking to the intestinal lamina propria (LP) and is a major therapeutic target in inflammatory bowel disease (IBD). Although integrin (Itg) β7 has been extensively studied in T-cell recruitment, its role in protective mucosal humoral immunity during chronic ileitis … Read more

In situ vaccination, low-dose targeted radionuclide therapy, and immune checkpoint inhibition eradicate poorly immunogenic metastatic tumors in murine cancer models

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Cancer Immunol Res. 2026 Jul 8. doi: 10.1158/2326-6066.CIR-25-1475. Online ahead of print. ABSTRACT Focal radiotherapy can provide an in situ vaccine (ISV) effect that may prime adaptive antitumor immunity, which can be augmented by combination with intratumoral immune adjuvants and systemic immune checkpoint inhibition. However, propagation of an antitumor immune response is not consistently achieved … Read more

Inflammatory genital strain of Chlamydia trachomatis elicits a Th17 immune response

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J Immunol. 2026 Jun 7;215(6):vkag177. doi: 10.1093/jimmun/vkag177. ABSTRACT In humans, infection with Chlamydia trachomatis can result in chronic infection with severe reproductive consequences. The immune response elicited by natural infection fails to protect against reinfection and can contribute to tissue inflammation and damage. CD4+ T cells are key mediators of protection against C. trachomatis. However, … Read more

Epigenetic control of p53 activity in regulatory T cells maintains their identity to prevent inflammation

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J Immunol. 2026 Jun 7;215(6):vkag145. doi: 10.1093/jimmun/vkag145. ABSTRACT Regulatory T cells (Tregs) are critical guardians of immune homeostasis that must operate in diverse and often inflammatory conditions. However, the mechanisms that Tregs use to maintain their stability and function, especially in response to the stresses of distinct microenvironments, remain incompletely understood. Previous work identified the … Read more

Adenosine as a metabolic checkpoint in CD8+ T cell dysfunction. Arden O Edgerton

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Trends Immunol. 2026 Jul 8:S1471-4906(26)00161-4. doi: 10.1016/j.it.2026.06.005. Online ahead of print. ABSTRACT CD8+ T cell dysfunction, characterized by impaired effector function, proliferative capacity, and sustained inhibitory receptor expression, limits immune control in both cancer and chronic viral infections. Despite arising from distinct disease processes, these conditions induce a shared state of CD8+ T cell dysfunction, … Read more

Homeostatic and inflammatory functions of pulmonary GM-CSF. Antonie Lechner

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Mucosal Immunol. 2026 Jul 7:100380. doi: 10.1016/j.mucimm.2026.100380. Online ahead of print. ABSTRACT Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that predominantly acts on myeloid cells. Although decades of research have revealed diverse functions of GM-CSF during inflammation across tissues, it exerts important homeostatic functions, most notably in the lung. Extensive studies have established the essential … Read more

Specialized pro-resolving mediators regulate in vitro human airway epithelial resistance to Aspergillus fumigatus. Khadeeja Adam Sy

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Mucosal Immunol. 2026 Jul 7:100379. doi: 10.1016/j.mucimm.2026.100379. Online ahead of print. ABSTRACT Cystic fibrosis (CF) is caused by mutations in the CFTR gene resulting in alterations in the immune functions of the airway epithelium, including reduced biosynthesis of the specialized pro-resolving lipid mediators (SPMs). Aspergillus fumigatus is the most isolated filamentous fungus in patients with … Read more

The food additive microbial transglutaminase is a potential new environmental inducer of autoimmune diseases

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Curr Opin Immunol. 2026 Jul 7;101:102812. doi: 10.1016/j.coi.2026.102812. Online ahead of print. ABSTRACT Microbial transglutaminase (mTG) is a frequently used processed food additive, and the consumption of its cross-linked complexes is rapidly expanding. Despite numerous reports concerning its public safety, it is designated as a processing aid and classified as safe for use. mTG and/or … Read more

Mapping the synovial immune ecosystem in rheumatoid arthritis: cellular cartography and pathotype-guided immune restoration

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Curr Opin Immunol. 2026 Jul 7;101:102811. doi: 10.1016/j.coi.2026.102811. Online ahead of print. ABSTRACT Rheumatoid arthritis (RA) is not a uniform inflammatory pannus. It is a spatially organized, stage-dependent synovial immune ecosystem. Cellular cartography resolves synovitis into lymphoid, myeloid, stromal, and neuroimmune niches that track erosive disease, fibroproliferation, and pain-dominant states. Ecosystem state can differ between … Read more

Bronchiectasis in Inborn Errors of Immunity: Prevalence, Predictors, and Cardiopulmonary Complications in a Genetically Characterized Cohort

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J Clin Immunol. 2026 Jul 8. doi: 10.1007/s10875-026-02044-8. Online ahead of print. ABSTRACT PURPOSE: Bronchiectasis poses a serious but incompletely defined burden in patients with inborn errors of immunity (IEI). We determined its prevalence, independent predictors, and cardiopulmonary complications in a genetically characterized IEI cohort to inform care in this vulnerable population. METHODS: We conducted … Read more

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