inmunoadmin

Enhancement of ferroptosis in escape variant tumor cells by IFN-γ derived from antigen-specific T cells controls tumor with heterogeneity

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Cancer Immunol Res. 2026 Jul 3. doi: 10.1158/2326-6066.CIR-25-0175. Online ahead of print. ABSTRACT Tumor masses often exhibit heterogeneity, including escape variant clones that lack antigen-presenting machinery and/or tumor antigens, which poses a major challenge to immunotherapy. Ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation, has been shown to effectively induce cell … Read more

Autofluorescence enables detection and quantification of EETosis in human leukocyte cultures​Masashi Akiyama on 3 de July de 2026 at 10:00

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J Leukoc Biol. 2026 Jul 3:qiag096. doi: 10.1093/jleuko/qiag096. Online ahead of print. ABSTRACT Eosinophils are leukocytes involved in defense against multicellular parasites and other pathogens. Like neutrophils, eosinophils can undergo a cytolytic form of cell death known as eosinophil extracellular trap cell death (EETosis), during which they release DNA and cytoplasmic granules to form eosinophil … Read more

Cold Atmospheric Plasma as an Immunomodulator: Suppression of T-cell Hyperactivation and Graft-versus-Host Disease via Redox Regulation​Thoh Maikho on 3 de July de 2026 at 10:00

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J Leukoc Biol. 2026 Jul 3:qiag066. doi: 10.1093/jleuko/qiag066. Online ahead of print. ABSTRACT Cold Atmospheric Plasma (CAP) has garnered significant attention in biomedical science, owing to its wide therapeutic applications in wound healing, disinfection, dentistry, cancer care and inflammation. Although, anti-inflammatory effects of CAP are studied, there are no reports investigating its effect on T … Read more

Helminths hijack the TGFβ receptor to promote a pro-regenerative program in the intestinal stem cell compartment. Danielle Karo-Atar

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Mucosal Immunol. 2026 Jul 2:100372. doi: 10.1016/j.mucimm.2026.100372. Online ahead of print. ABSTRACT The intestine is a multifunctional tissue relying on multipotent stem cells to establish a repertoire of epithelial cell lineages. We have previously shown that the enteric parasitic nematode Heligmosomoides polygyrus bakeri (Hpb) directly regulates the intestinal stem cell compartment, tuning the epithelium to … Read more

Bioinformatics roadmap for characterizing the gut microbiome to study its interactions and associations with the gut mucosal immune system. Muhammad Zohaib Anwar

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Mucosal Immunol. 2026 Jul 2:100375. doi: 10.1016/j.mucimm.2026.100375. Online ahead of print. ABSTRACT Cataloging the gut microbiome and understanding its interactions and association with the host immune system remains relevant to identify potential treatments for complex chronic diseases, including cancer. Studying the gut microbiome is more accessible than ever, thanks to the dramatic cost reduction of … Read more

IL-33 scripts cancer immunity. Marek Wagner

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Trends Immunol. 2026 Jul 2:S1471-4906(26)00162-6. doi: 10.1016/j.it.2026.06.006. Online ahead of print. ABSTRACT Interleukin-33 (IL-33) is classically viewed as an alarmin, but in cancer, it may do more than merely initiate immunity. I propose that IL-33 scripts the trajectory of immunity through interconnected regulatory layers that influence how host responses are organized and ultimately resolved into … Read more

Complement C3 deficiency increases the effector and cytotoxic functions of NK cells and suppresses tumor growth

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J Immunol. 2026 Jun 7;215(6):vkag157. doi: 10.1093/jimmun/vkag157. ABSTRACT The complement system and natural killer (NK) cells play crucial roles in tumor growth and metastasis. The role of the complement system in affecting the phenotype and anti-tumor function of NK cells remains poorly understood. Using the B16F10 mouse melanoma model, we demonstrated that NK cells from … Read more

FTR85 negatively regulates type I IFN antiviral signaling pathway by promoting K48-linked polyubiquitination of IRF3

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J Immunol. 2026 Jun 7;215(6):vkag132. doi: 10.1093/jimmun/vkag132. ABSTRACT The finTRIM (FTR) subfamily, a group of fish-specific tripartite motif proteins, has arisen through gene duplication events specific to particular genera or species. However, the regulatory mechanisms of FTR in antiviral immune response remains largely unknown. In the present study, we identified a fish novel tripartite motif … Read more

An MR1-specific nanobody capable of blocking MR1T cell activation

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J Immunol. 2026 Jun 7;215(6):vkag094. doi: 10.1093/jimmun/vkag094. ABSTRACT MR1 is a non-polymorphic, ubiquitously expressed, MHC class I-like antigen-presenting molecule that presents small-molecule metabolites to T cells. Studies have shown that MR1 plays a role in microbial infection, inflammation, and tumor immunity. The antigens it presents include metabolites of microbial and self-origin as well as small-molecule … Read more

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