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SHIP Blocks (MDP+LPS)-Induced Synergy in Macrophages Independent of Catalytic Activity​Yvonne C F Pang on 27 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 27:qiag090. doi: 10.1093/jleuko/qiag090. Online ahead of print. ABSTRACT Macrophages coordinate cytokine responses by integrating signals from pattern recognition receptors including NOD2 and TLR4. NOD2 detects muramyl dipeptide derived from bacterial peptidoglycan, and TLR4 recognizes lipopolysaccharide in the outer membrane of Gram-negative bacteria. NOD2 and TLR4 signals synergize to enhance cytokine … Read more

CD43: Recent Advances and Emerging Functions​Mariana Diupotex on 27 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 27:qiag084. doi: 10.1093/jleuko/qiag084. Online ahead of print. ABSTRACT Originally characterized for its roles in T-cell activation and adhesion, CD43 is a prominent mucin-like sialoglycoprotein expressed on hematopoietic cells. CD43 is broadly expressed across leukocyte populations, with its levels, molecular configuration, and ligand interactions varying by cell type, activation state, and … Read more

On or within: spatial determinants of antigen handling in the nasal turbinates

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Curr Opin Immunol. 2026 Jun 26;101:102808. doi: 10.1016/j.coi.2026.102808. Online ahead of print. ABSTRACT The SARS-CoV-2 pandemic has renewed interest in mucosal vaccines, yet these approaches have long struggled to generate durable protection against airway pathogens. A key limitation is the incomplete understanding of how upper airway antigens are handled to shape immune response quality and … Read more

The V158F polymorphism in human FcγRIIIa/CD16a defines opposing receptor responses when interacting with soluble immune complexes

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J Immunol. 2026 Jun 7;215(6):vkag160. doi: 10.1093/jimmun/vkag160. ABSTRACT The V158F polymorphism found in the human Fc receptor CD16a (also known as FcγRIIIa) is thought to influence autoimmune disorders and responses to IgG-based therapies. V158F is known to influence the IgG affinity, and thereby triggering of the CD16a receptor expressed on various immune cells. In contrast … Read more

Foxp1 controls Fezf2-dependent gene expression, mimetic mTEC diversity, and thymic central tolerance

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J Immunol. 2026 Jun 7;215(6):vkag168. doi: 10.1093/jimmun/vkag168. ABSTRACT Forkhead Box P1 (Foxp1) is a transcription factor critical for the proper development of multiple tissues. While Foxp1 has a well-described role in regulating adaptive immunity through modulation of T and B cells, a function in medullary thymic epithelial cells (mTECs) has not been reported. Here we … Read more

MAPK-activated protein kinase 2 orchestrates memory T-cell inflation in cytomegalovirus infection

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J Immunol. 2026 Jun 7;215(6):vkag170. doi: 10.1093/jimmun/vkag170. ABSTRACT Memory T-cell inflation is a distinctive immunological phenomenon observed during persistent viral infections such as cytomegalovirus (CMV). Unlike conventional memory T-cell responses, which contract after infection resolution, a subset of CMV-specific T cells undergoes a progressive and sustained expansion, termed “inflation”, which is thought to be critical … Read more

Peripheral Th17 immune signature associates with excellent response to anti-PD1/anti-PD-L1 therapy across solid tumors

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Cancer Immunol Res. 2026 Jun 26. doi: 10.1158/2326-6066.CIR-25-1611. Online ahead of print. ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed cancer care, at times generating durable partial or even complete responses in advanced cancers. However, only a minority of patients experience these “excellent” responses. Thus, there is a need for novel biomarkers that can identify those … Read more

Genetic deletion of the inflammatory bowel disease-associated risk gene Rgs14 aggravates experimental colitis

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J Immunol. 2026 Jun 7;215(6):vkag135. doi: 10.1093/jimmun/vkag135. ABSTRACT Regulators of G protein signaling (RGS) deactivate G proteins associated with G protein-coupled receptors (GPCRs), a large receptor family with diverse functions. Of the 20 RGS, the Rgs14 single-nucleotide polymorphism is associated with inflammatory bowel disease, and Rgs14 expression is higher in macrophages than in epithelial cells. … Read more

CSF1R-dependent macrophages control B cell development and function in the chicken immune system

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J Immunol. 2026 Jun 7;215(6):vkag143. doi: 10.1093/jimmun/vkag143. ABSTRACT Acquired immunity in mammals depends upon capture and presentation of antigens by specialized macrophage populations in splenic marginal zone and lymph node sinuses and follicular dendritic cells within germinal centers. Cells referred to as follicular dendritic cells in chickens express CSF1R, the receptor for CSF1 and IL34. … Read more

SLC1A5 augmentation bypasses NK cell transduction barriers to deliver complex CAR payloads

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J Immunol. 2026 Jun 7;215(6):vkag133. doi: 10.1093/jimmun/vkag133. ABSTRACT Reproducible and efficient genetic engineering of human NK cells remains a primary challenge to next-generation chimeric antigen receptor (CAR) therapies, specifically for larger constructs with multiple plasmids and transgenes. Lentiviral vectors (LVs) pseudotyped with baboon envelope (BaEV) outperform vesicular stomatitis virus G protein in transducing hematopoietic stem … Read more

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