inmunoadmin J Leukoc Biol. 2026 Jun 29:qiag091. doi: 10.1093/jleuko/qiag091. Online ahead of print. ABSTRACT Eosinophils are highly granulated white blood cells first identified as “granule blood cells” in the 19th century. In this review, we discuss techniques used to identify these unique cells and explore how they release a range of pro- and anti-inflammatory mediators. They … Read more
J Leukoc Biol. 2026 Jun 8;118(6):qiag062. doi: 10.1093/jleuko/qiag062. ABSTRACT The immunotherapy represents the most promising new cancer treatment approach but due to the high heterogeneity of the tumor microenvironment among patients, only a small portion of patients respond to a certain immunotherapy. Therefore, identifying the immune-related subtypes and immune molecular characteristics is of great guiding … Read more
J Leukoc Biol. 2026 Jun 8;118(6):qiag075. doi: 10.1093/jleuko/qiag075. ABSTRACT Autologous cell therapy is a patient-embraced approach to inflammatory disease. Murine models demonstrate that alternatively activated (or regulatory) macrophages can reduce the severity of disease, and human macrophages (M0) educated with interleukin-4 (M(IL4)) limit murine colitis. M0 and M(IL4) from healthy donors and individuals with Crohn’s … Read more
Cancer Immunol Res. 2026 Jun 29:OF1-OF2. doi: 10.1158/2326-6066.CIR-26-0635. Online ahead of print. ABSTRACT Immune checkpoint inhibitors (ICI) have had a transformative impact on cancer treatment. However, many patients still fail to respond to ICIs, underscoring the need to identify novel drivers of resistance. In this issue, Ou and colleagues identify single-stranded DNA binding protein 4 … Read more
J Clin Immunol. 2026 Jun 27. doi: 10.1007/s10875-026-02047-5. Online ahead of print. ABSTRACT TRNT1 deficiency (SIFD syndrome) is a rare inborn error of immunity characterized by sideroblastic anemia, immunodeficiency, periodic fevers, and developmental delay. We report two Romanian patients with genetically confirmed TRNT1 deficiency presenting with characteristic hematologic and immunologic abnormalities and a distinctive facial … Read more
Mucosal Immunol. 2026 Jun 27:100371. doi: 10.1016/j.mucimm.2026.100371. Online ahead of print. ABSTRACT Postbiotics offer improved safety and stability over live probiotics for modulating intestinal immunity, yet the receptor-mediated mechanisms underlying mucosal tolerance remain unclear. Nucleotide-binding oligomerization domain 2 (NOD2), a cytosolic sensor of bacterial cell wall components and a major genetic risk factor for inflammatory … Read more
Semin Immunol. 2026 Jun 27;83:102048. doi: 10.1016/j.smim.2026.102048. Online ahead of print. ABSTRACT Inflammation is a defining feature of the tumor microenvironment (TME) and a key driver of cancer progression. Among inflammatory mediators, the interleukin-1 (IL-1) family of cytokines serves as a central mediator linking tissue damage, metabolic stress and microbial cues to innate immune activation. … Read more
Curr Opin Immunol. 2026 Jun 27;101:102807. doi: 10.1016/j.coi.2026.102807. Online ahead of print. ABSTRACT In this review, we detail the features of barrier germinal centers (GC) that form in tertiary lymphoid structures (TLSs) within non-immune organs that host a local microbiome, and posit a framework of immunity where TLS-GCs created at barrier sites are a key … Read more
Curr Opin Immunol. 2026 Jun 27;101:102810. doi: 10.1016/j.coi.2026.102810. Online ahead of print. ABSTRACT Ocular sarcoidosis is a frequent manifestation of sarcoidosis and may occur most commonly affecting adults between 30 and 60 years old. Uveitis may be anterior, intermediate, posterior, or present as panuveitis, with marked heterogeneity in severity and clinical course. Diagnosis relies on … Read more
J Immunol. 2026 Jun 7;215(6):vkag151. doi: 10.1093/jimmun/vkag151. ABSTRACT Inflammatory diseases arise from complex interactions between immune signaling and cellular stress. Although endoplasmic reticulum (ER) stress is a key modulator of immunity, the mechanisms by which it promotes inflammatory pathology remain incompletely understood. Notably, ER stress-induced NF-κB activation alone is insufficient to account for robust IL-6 … Read more
