inmunoadmin J Immunol. 2026 Jun 7;215(6):vkag137. doi: 10.1093/jimmun/vkag137. ABSTRACT In the canonical model of VDJ recombination, a single diversity (D) gene is incorporated into the complementarity-determining region 3 (CDR3) to produce a T cell receptor δ (TCRδ; TRD) or TCRβ (TRB) chain. But by constructing a dataset of more than 2.7 million TRD CDR3 sequences from … Read more
J Leukoc Biol. 2026 Jun 26:qiag087. doi: 10.1093/jleuko/qiag087. Online ahead of print. ABSTRACT Basophils secrete histamine and IL-4/13 when co-cultured with human lung adenocarcinoma cells (A549 cells). Previous studies have revealed that this interaction is dependent on Galectin-3 expression on the surface of A549 cells (EC-Gal-3), IgE present on the surface of IL-3 primed basophils, … Read more
Ex vivo characterization of antigen-specific CD8 T cells is crucial but often limited by expansion bottlenecks. We identify p16INK4A as a key regulator of TCR-dependent and homeostatic proliferation. CRISPR/Cas9 deletion of CDKN2A rescues proliferation and improves IFN-γ secretion while maintaining TCR-dependency, enabling robust expansion for functional characterization and clinical applications. ABSTRACT The possibility of enhancing … Read more
Trends Immunol. 2026 Jun 25:S1471-4906(26)00137-7. doi: 10.1016/j.it.2026.05.012. Online ahead of print. ABSTRACT Mitochondrial calcium (mtCa2+) has long been framed as a bioenergetic regulator, yet evidence redefines it as a relevant immunometabolic switch. Within the tumor microenvironment, the mitochondrial calcium uniporter (MCU) complex and the NCLX-TMEM65 efflux axis maintain a ‘Goldilocks zone’ of Ca2+ homeostasis. This … Read more
Mucosal Immunol. 2026 Jun 25:100369. doi: 10.1016/j.mucimm.2026.100369. Online ahead of print. ABSTRACT CD4+ T helper (Th) cell responses to commensal microbiota are linked to Inflammatory Bowel Disease (IBD), yet how Th programs coexist and evolve in human tissues remains poorly defined. Here, we profiled CD4+ memory T cells in intestinal biopsies using immunological and histological … Read more
Mucosal Immunol. 2026 Jun 25:100370. doi: 10.1016/j.mucimm.2026.100370. Online ahead of print. ABSTRACT GPR15 is a colon homing receptor, but its pattern of expression among gut intestinal intraepithelial lymphocytes and its role on intestinal intraepithelial lymphocyte and epithelial homeostasis, as well as systemic metabolism and hormones remain unknown. GPR15L is the only ligand for GPR15 described … Read more
Mucosal Immunol. 2026 Jun 25:100368. doi: 10.1016/j.mucimm.2026.100368. Online ahead of print. ABSTRACT Dysregulation of regulatory T cells (Tregs) is a hallmark of immune imbalance in ulcerative colitis (UC), in which their suppressive function relies heavily on post-translational modifications and the stabilization of the transcription factor Foxp3. However, the upstream regulatory mechanisms remain poorly understood. Here, … Read more
J Leukoc Biol. 2026 Jun 25:qiag088. doi: 10.1093/jleuko/qiag088. Online ahead of print. ABSTRACT Limosilactobacillus reuteri (formerly Lactobacillus reuteri) is a well-studied commensal bacterium known for various health benefits. Our recent findings reveal that the human-derived strain L. reuteri CF48-3A enhances endogenous neonatal immunoglobulin A (IgA) production in mice. In a comparative analysis between the human … Read more
J Immunol. 2026 Jun 7;215(6):vkag125. doi: 10.1093/jimmun/vkag125. ABSTRACT Severe trauma triggers a dynamic disturbance of immune function that can progress from early hyperinflammation to prolonged dysregulation, increasing patient vulnerability to infection and chronic critical illness (CCI). To identify immune features linked to different postinjury clinical trajectories, we prospectively evaluated severely injured trauma patients and categorized … Read more
J Immunol. 2026 Jun 7;215(6):vkag139. doi: 10.1093/jimmun/vkag139. ABSTRACT Protective immunity is induced by both, wild-type measles virus (WT MeV) and live-attenuated (LA) measles virus vaccine (LAMV), affording the opportunity to compare common and selective immunological underpinnings of immune protection. Here, peripheral blood mononuclear cells (PBMCs) were collected from rhesus macaques at several timepoints after infection … Read more
