inmunoadmin

This review explores how mesenteric adipose tissue, particularly creeping fat, contributes to intestinal inflammation through dysregulated adipokine signalling. We explore how metabolic stress alters immune-adipose interactions and promotes disease progression. Insights from mechanistic studies highlight mesenteric adipose tissue as a key driver of inflammation and a potential therapeutic target. ABSTRACT Inflammatory bowel disease, including Crohn’s … Read more

Inducing memory inflation (MI) is a promising future vaccination strategy. We show that spread-defective cytomegalovirus does not induce MI in the absence of CD4+ T cells. Support from CD4+ T cells can drive effector differentiation of MI cells, even late in the response, and contributes to long-term response maintenance. ABSTRACT Memory inflation (MI) is a … Read more

This review highlights T cell exhaustion as an adaptive differentiation trajectory, not dysfunction, showing how precursor, intermediate, and terminal exhausted states maintain antigen recognition while limiting tissue damage in chronic immune activation. ABSTRACT T cell exhaustion is now recognised as a structured, antigen-driven differentiation programme rather than a state of cellular fatigue. Under sustained antigen … Read more

This review will explore the role of the factor H-related (FHR) proteins in age-related macular degeneration (AMD), their accumulation in the outer blood/retinal barrier, and how they may contribute to barrier dysfunction and inflammation. ABSTRACT Age-related macular degeneration (AMD) is the third most common form of blindness in the Western world, with a predicted 288 … Read more