inmunoadmin

Shifting From Systemic to Precision‐Targeted Complement Therapies: Opportunities and Hurdles. [[{“value”:”Marco Mannes, Wioleta M. Zelek, Leendert A. Trouw”}]]

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Complement therapeutics have expanded considerably, but systemic inhibitors remain limited by infection risks, breakthrough events, and loss of physiological functions. Emerging targeted approaches aim for organ-, tissue-, or cell-specific modulation of complement activity, potentially offering greater precision while reducing treatment burden and preserving beneficial complement functions. ABSTRACT The landscape of complement therapeutics has significantly broadened … Read more

Metabolic regulatory nodes of the inflammasome and inflammatory cell death. Ein Lee

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Trends Immunol. 2026 Jun 19:S1471-4906(26)00139-0. doi: 10.1016/j.it.2026.06.002. Online ahead of print. ABSTRACT Inflammation is a metabolically intensive and tightly regulated process, driven primarily by innate immune cells. Cellular metabolism actively instructs immune signaling and cell fate decisions. Bioenergetic pathways, including glycolysis, mitochondrial respiration, and the tricarboxylic acid cycle, reshape cytokine production and regulate inflammatory cell … Read more

Disseminated Tuberculosis and Early-Onset SLE in a Child with a Novel STAT1 Gain-of-Function Mutation: a Case Report

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J Clin Immunol. 2026 Jun 19;46(1):67. doi: 10.1007/s10875-026-02040-y. ABSTRACT BACKGROUND: Gain-of-function (GOF) mutations in the STAT1 gene result in heightened interferon signaling and impaired IL-17 immunity. While chronic mucocutaneous candidiasis (CMC) remains the hallmark feature, affected individuals often display a broader phenotype including viral infections, mycobacterial susceptibility, and autoimmune diseases. CASE PRESENTATION: We describe a … Read more

Transmembrane orientation and extracellular juxtamembrane residues of GP130 are critical for signal transduction

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J Immunol. 2026 Jun 7;215(6):vkag118. doi: 10.1093/jimmun/vkag118. ABSTRACT Glycoprotein 130 (GP130) is an archetypal class I cytokine receptor that serves as a shared signalling subunit for a group of cytokines known as interleukin 6 (IL-6)-type cytokines. GP130 does not have an intrinsic kinase activity and relies on Janus kinases (JAK) 1, 2, or Tyrosine kinase … Read more

The anti-CD33 antibody drug conjugate gemtuzumab ozogamicin depletes and functionally resets CD33+ myeloid-derived suppressor cells in patients with metastatic cancer: a phase II single arm, open label trial​Carmela De Santo on 18 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 18:qiag083. doi: 10.1093/jleuko/qiag083. Online ahead of print. ABSTRACT We previously demonstrated that the anti-CD33 antibody drug conjugate, gemtuzumab ozogamicin (GO) binds CD33-expressing monocytic myeloid-derived suppressor cells (M-MDSCs), is internalised, and decreases their viability. Treatment of MDSCs with GO restores T-cell proliferation in co-culture, overcomes M-MDSC suppression of CAR-T-cell proliferation, and … Read more

HIF-1α in macrophage polarization: roles in immunometabolism and autoimmune diseases​Dongye Li on 18 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 18:qiag082. doi: 10.1093/jleuko/qiag082. Online ahead of print. ABSTRACT Hypoxia-inducible factor-1α (HIF-1α) is a central regulator of cellular responses to hypoxia and plays a pivotal role in immune cell activation and functional reprogramming. This review summarizes how HIF-1α modulates inflammatory responses through metabolic regulation and examines its mechanistic involvement in autoimmune … Read more

Humoral Immune Abnormalities in Transient Childhood Neutropenia: Insights From a 10-year Cohort Study in a Tertiary Center

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J Clin Immunol. 2026 Jun 18. doi: 10.1007/s10875-026-02042-w. Online ahead of print. ABSTRACT PURPOSE: Transient neutropenia in early childhood is a relatively common condition often associated with neutrophil-specific autoantibodies; however, its connection to broader humoral immune system abnormalities remains poorly understood. METHODS: The current study investigated this relationship through a retrospective cohort analysis at a … Read more

Increased ULBP1 by doxorubicin sensitizes neuroblastoma to γδT-cell cytotoxicity

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J Immunol. 2026 Jun 7;215(6):vkag144. doi: 10.1093/jimmun/vkag144. ABSTRACT Neuroblastoma (NB) is the most common extracranial solid tumor in children and remains a major therapeutic challenge in high-risk patients because of frequent recurrence and metastasis. γδT cells are a unique lymphocyte subset with potent antitumor activity and are widely distributed in NB tumors. However, the immunosuppressive … Read more

The Memory Inflation Response Against Spread‐Defective CMV Requires Priming‐Independent CD4+ T Cell Help. [[{“value”:”Jack Barton, Yeonsu Kim, Matthias T. Warkotsch, Luka Cicin‐Sain, Mateusz P. Poltorak, Veit R. Buchholz, Dirk H. Busch”}]]

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Inducing memory inflation (MI) is a promising future vaccination strategy. We show that spread-defective cytomegalovirus does not induce MI in the absence of CD4+ T cells. Support from CD4+ T cells can drive effector differentiation of MI cells, even late in the response, and contributes to long-term response maintenance. ABSTRACT Memory inflation (MI) is a … Read more

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