inmunoadmin

A neuro-epithelial unit regulates immunohomeostasis at barrier surfaces. Manuel O Jakob

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Mucosal Immunol. 2026 Jun 17:100363. doi: 10.1016/j.mucimm.2026.100363. Online ahead of print. ABSTRACT Barrier tissues are sites of constant environmental exposure and require tightly coordinated mechanisms to maintain immune homeostasis while preserving tissue integrity. Emerging evidence supports the concept of a neuro-epithelial unit, in which neurons and epithelial cells function as integrated regulatory modules. In this … Read more

ADAR1 deficiency in pancreatic cancer cells potentiates cDC1 activation and promotes sensitization to immunotherapy

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Cancer Immunol Res. 2026 Jun 17. doi: 10.1158/2326-6066.CIR-25-1626. Online ahead of print. ABSTRACT Pancreatic cancer responds poorly to immunotherapy, primarily due to poor activation of CD8+ T cells and their limited infiltration into the tumor tissue. Strategies to enhance CD8+ T-cell priming and function are therefore critical for improving immunotherapeutic efficacy in pancreatic cancer. The … Read more

Engineering human synovial organoids as predictive ecosystems for disease modeling and therapeutic response in rheumatology

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Curr Opin Immunol. 2026 Jun 16;101:102793. doi: 10.1016/j.coi.2026.102793. Online ahead of print. ABSTRACT The synovium is a critical site for the initiation and persistence of inflammatory joint diseases, including rheumatoid arthritis (RA), osteoarthritis (OA), and gout. Conventional 2D cultures and animal models fail to recapitulate the multicellular organization, mechanical regulation, and inter-tissue communication that shape … Read more

T cell control of the intestinal barrier and gut microbiota during ageing. Manuel M Gómez de Las Heras

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Trends Immunol. 2026 Jun 16:S1471-4906(26)00105-5. doi: 10.1016/j.it.2026.05.001. Online ahead of print. ABSTRACT The epithelial, microbial, and immune components of the intestinal barrier coexist in harmony to prevent undesirable inflammatory outcomes and ensure homeostasis in the host. In this review, we outline molecular mechanisms by which T cells regulate intestinal homeostasis and how the ageing-associated dysfunction … Read more

Neutrophils in Tumorigenesis and Progression: Dual Roles and Clinical Translation​Kexin Hu on 16 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 16:qiag079. doi: 10.1093/jleuko/qiag079. Online ahead of print. ABSTRACT Neutrophils, the most abundant innate immune cells, act as first responders in host defense via phagocytosis, degranulation, ROS production and Neutrophil Extracellular Traps (NETs) formation. Emerging evidence reveals that neutrophils are highly plastic and heterogeneous, acting as critical regulators in tumor biology. … Read more

Lymphatic endothelial cells actively shape immune responses in the lungs

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Curr Opin Immunol. 2026 Jun 15;101:102802. doi: 10.1016/j.coi.2026.102802. Online ahead of print. ABSTRACT Lymphatic vessels maintain fluid balance and immune protection by transporting fluid, solutes and cells from tissue interstitial spaces to lymph nodes. The lymphatic endothelial cells that form lymphatics differentiate throughout the body to fulfil organ-specific roles. In the lungs, specialised pulmonary lymphatic … Read more

Human XIRP1 is a new podosome protein targeting cytosolic bacteria as part of the IFN-γ defense program

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J Immunol. 2026 Jun 7;215(6):vkag116. doi: 10.1093/jimmun/vkag116. ABSTRACT Interferon-gamma (IFN-γ) is a powerful transactivating signal eliciting hundreds of IFN-stimulated genes (ISGs) in humans to help combat infection. Most ISGs remain uncharacterized, and here we searched for actin-binding candidates that could potentially target intracellular pathogens to block their spread or promote immune cell migration into infected … Read more

Context-dependent androgen control of T cell immunity. Jianhua Xiong

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Trends Immunol. 2026 Jun 15:S1471-4906(26)00156-0. doi: 10.1016/j.it.2026.06.004. Online ahead of print. ABSTRACT While androgen deprivation is widely used in urological oncology to restrain tumor growth and prevent T cell exhaustion, Lee et al. reveal a striking reversal in glioblastoma. In glioblastoma, androgen loss triggers microglial cytokines, activates the hypothalamic-pituitary-adrenal axis, and induces glucocorticoid-dependent T cell … Read more

Interleukin-1-mediated inflammatory memory: Protective training or maladaptive tumor imprinting?. Despoina Xanthopoulou

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Semin Immunol. 2026 Jun 15;83:102047. doi: 10.1016/j.smim.2026.102047. Online ahead of print. ABSTRACT Interleukin-1 (IL-1) exerts a pivotal role in the regulation of innate immune responses and inflammatory processes. Beyond its local effects at the site of inflammation, IL-1 acts as a systemic regulator of hematopoiesis by reprogramming hematopoietic stem and progenitor cells (HSPCs), thereby shaping … Read more

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