Congenital cytomegalovirus infection drives oligoclonal expansion of cytotoxic γδ T cells from early fetal progenitors

J Immunol. 2026 Jun 7;215(6):vkag099. doi: 10.1093/jimmun/vkag099. ABSTRACT Gamma delta (γδ) T cells emerge early during human gestation and are uniquely equipped to protect the fetus and infant following infection, due to their innate-like recognition of conserved molecular ligands. Following congenital cytomegalovirus infection (cCMV), Vδ1 T cells have been shown to expand, differentiate, and upregulate … Read more

Raynaud’s phenomenon: a vascular or an autoimmune-mediated disorder? Facts and fancy

Curr Opin Immunol. 2026 Jun 13;101:102803. doi: 10.1016/j.coi.2026.102803. Online ahead of print. ABSTRACT Raynaud’s phenomenon (RP) is a common vasospastic disorder characterized by transient digital ischemia triggered by cold exposure or emotional stress. It is classified as primary or secondary, the latter often associated with autoimmune connective tissue diseases such as systemic sclerosis, mixed connective … Read more

p120-catenin enhances macrophage efferocytosis and facilitates resolution of lung inflammatory injury

J Immunol. 2026 Jun 7;215(6):vkag109. doi: 10.1093/jimmun/vkag109. ABSTRACT Defective resolution of inflammation following sepsis contributes to persistent immune dysfunction and increased morbidity and mortality worldwide. Efficient clearance of apoptotic polymorphonuclear neutrophils (PMNs) by macrophages, a process known as efferocytosis, is essential for resolving inflammation, promoting tissue repair, and restoring immune homeostasis; however, the molecular mechanisms … Read more

Parenteral vaccination protects against mucosal Salmonella infection by inducing liver tissue resident memory CD4 T cells

J Immunol. 2026 Jun 7;215(6):vkag138. doi: 10.1093/jimmun/vkag138. ABSTRACT Salmonella enterica is a gastrointestinal pathogen that causes a variety of intestinal and systemic clinical disease. Vaccine development for systemic salmonellosis requires a deeper understanding of protective mechanisms and the relative contribution of mucosal and systemic host responses to bacterial elimination. Here, we examined the relative importance … Read more

A novel monocyte-derived antigen presenting cell-T regulatory cell axis contributes to skin wound healing and is impaired in diabetic mice

J Immunol. 2026 Jun 7;215(6):vkag128. doi: 10.1093/jimmun/vkag128. ABSTRACT Despite a vast literature on the role of macrophages in wound healing, the role of dermal monocyte (Mo)-derived antigen presenting cells (APC) has received scant attention. Using scRNAseq and flow cytometry, we identify a population of APC that is prominent in wounds of non-diabetic mice but is … Read more

Rotavirus-specific intestinal resident memory T cells induced by oral vaccination in early-life mice may contribute to protective immunity​Catherine Montenegro on 13 de June de 2026 at 10:00

J Leukoc Biol. 2026 Jun 13:qiag080. doi: 10.1093/jleuko/qiag080. Online ahead of print. ABSTRACT Resident memory T cells (Trm) are key mediators of protective immunity at barrier sites, yet their development during early life remains poorly defined. Here, we show that early-life oral vaccination with a heterologous rhesus rotavirus (RV) induces short-lived intestinal Trm that are … Read more

CCDC77 and SLC45A3 mediate the genetic mechanism of Hashimoto’s thyroiditis through IL-6. [[{“value”:”Rui Wang Yuhao Jiao Shengjun Chai Chunmei Cai a Research Center for High Altitude Medicine, Qinghai University Medical College, Xining, P. R. China b Key Laboratory of the Ministry of High Altitude Medicine, Qinghai University Medical College, Xining, P. R. China c Key Laboratory of Applied Fundamentals of High Altitude Medicine, (Qinghai-Utah Joint Key Laboratory of Plateau Medicine), Qinghai University Medical College, Xining, P. R. China d Laboratory for High Altitude Medicine of Qinghai Province, Qinghai University Medical College, Xining, P. R. China”}]]

Volume 59, Issue 1, December 2026.

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