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Preselection CD4+CD8+ thymocytes modulate TCR responsiveness following TCRβ selection

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J Immunol. 2026 Jun 7;215(6):vkag105. doi: 10.1093/jimmun/vkag105. ABSTRACT Modulation of T cell receptor (TCR) sensitivity during positive selection is critical to avoid negative selection and direct thymocytes into their appropriate lineage. Thymocytes just prior to positive selection (preselection) are highly responsive to low affinity self-ligands and are also actively rearranging their TCRα locus as they … Read more

Virus-specific resident memory T cell networks sustain immunity in human oral mucosa. Florian Winkler

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Mucosal Immunol. 2026 Jun 11:100362. doi: 10.1016/j.mucimm.2026.100362. Online ahead of print. ABSTRACT BACKGROUND: Durable protection against viral infections relies on tissue-resident memory T (TRM) cells at pathogen entry sites. The oral cavity is a critical mucosal barrier frequently exposed to viral pathogens; however, the phenotypic characteristics and spatial organization of virus-specific T cells in the … Read more

RUNX2 promotes chromatin accessibility and WNT signaling in inflamed intestinal epithelial cells. Rodolfo I Cabrera-Silva

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Mucosal Immunol. 2026 Jun 11:100361. doi: 10.1016/j.mucimm.2026.100361. Online ahead of print. ABSTRACT Ulcerative colitis (UC) is characterized by chronic mucosal inflammation, recurrent epithelial injury, and impaired colonic mucosal wound healing. While WNT/β-catenin dysregulation has been reported in UC, the mechanisms of such abnormalities remain unclear. To investigate epithelial intrinsic alterations associated with UC, we performed … Read more

DNA hypomethylating agents preserve T cell stemness and potentiate the efficacy of CD3-bispecific antibodies

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Cancer Immunol Res. 2026 Jun 11. doi: 10.1158/2326-6066.CIR-25-1420. Online ahead of print. ABSTRACT Bispecific antibodies targeting tumor-associated antigens and CD3 are promising therapeutic agents for both solid and hematologic cancers. CD3-bispecifics induce T cell activation and cytotoxicity; however, prolonged TCR stimulation can lead to chromatin rewiring and T cell dysfunction, thereby limiting their full therapeutic … Read more

Topical resiquimod elicits systemic protection and improves anti-PD1 therapy in melanoma via priming of CD8+ T cells

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Cancer Immunol Res. 2026 Jun 11. doi: 10.1158/2326-6066.CIR-25-0998. Online ahead of print. ABSTRACT The Toll-like receptor (TLR) 7/8 agonist resiquimod shows promise for treating cutaneous T cell lymphoma and actinic keratosis, yet its mechanism of action remains unclear. We demonstrated that topical resiquimod significantly inhibited melanoma growth across various genetic and syngeneic mouse models, prolonged … Read more

Conjugated bilirubin reduces hepatitis E virus infectivity by modulating immunometabolic processes​Javier Orozco-Cordoba on 11 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 11:qiag078. doi: 10.1093/jleuko/qiag078. Online ahead of print. ABSTRACT Despite the landmark discovery of the hepatitis E virus (HEV) four decades ago and its status as the leading cause of viral hepatitis worldwide, the infection remains overlooked in numerous countries. Currently, there are no approved treatments for hepatitis E or licensed … Read more

A Narrative Review of the mtDNA-Stimulated Inflammatory Axis in Sepsis-Induced Acute Lung Injury: Cellular Mechanisms and Therapeutic Targeting​Shuqi Ma on 11 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 11:qiag077. doi: 10.1093/jleuko/qiag077. Online ahead of print. ABSTRACT Sepsis-induced acute lung injury (SALI) represents a life-threatening condition with complex pathophysiology. Emerging evidence highlights the mitochondrial DNA (mtDNA)-stimulated inflammatory axis as a pivotal mechanism driving pulmonary inflammation. This narrative review elucidates how mtDNA, released upon cellular damage, acts as a potent … Read more

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