inmunoadmin

Tregitopes derived from canine proteins can enhance T regulatory lymphocytes frequency in dog PBMC culture in vitro​Paweł Szydłowski on 9 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 10:qiaf143. doi: 10.1093/jleuko/qiaf143. Online ahead of print. ABSTRACT Adoptive cell therapy using ex vivo expanded autologous Tregs could be a novel therapeutic approach for cell-based immunotherapy in dogs. This study aimed to expand dog Treg lymphocytes via the use of tregitopes. PBMCs were isolated from healthy beagle dogs and stimulated … Read more

Group 3 innate lymphoid cell-derived CSF2 tunes homeostasis of tissue macrophages and neutrophils. S L Tai

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Mucosal Immunol. 2025 Oct 7:S1933-0219(25)00106-0. doi: 10.1016/j.mucimm.2025.10.004. Online ahead of print. ABSTRACT Group 3 innate lymphoid cells (ILC3) are tissue-resident lymphocytes that contribute to tissue and immune homeostasis. Alterations in ILC3 development or deficiency in their effector functions have beneficial and detrimental outcomes on chronic inflammation, host defense and barrier integrity. Although research has progressed … Read more

Actin regulation of neutrophil effector mechanisms in health and disease​Noelle Pisacano on 9 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 9:qiaf142. doi: 10.1093/jleuko/qiaf142. Online ahead of print. ABSTRACT Neutrophils are central to immune responses in health and disease, and their ability to deform correlates with their functional responses. In health, reorganisation of the neutrophil cytoskeleton allows neutrophils to carry out their effector mechanisms. However, in the disease state, dysregulation of … Read more

Non-neutralizing antibodies against SARS-CoV-2 nucleocapsid protein mediate variant transcendent antibody-dependent cellular cytotoxicity

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J Immunol. 2025 Oct 8:vkaf123. doi: 10.1093/jimmun/vkaf123. Online ahead of print. ABSTRACT Vaccination strategies and correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly focused on the spike (S) protein and neutralizing antibodies. However, the rapid emergence of SARS-CoV-2 variants has reduced the effectiveness of spike-based vaccines and monoclonal antibodies. It … Read more

Pivotal role of voltage-dependent anion channel 2 in pyroptosis induced by spring viremia of carp virus in fish cells

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J Immunol. 2025 Oct 8:vkaf154. doi: 10.1093/jimmun/vkaf154. Online ahead of print. ABSTRACT Spring viremia of carp virus (SVCV) represents a significant threat to cyprinids, particularly common carp (Cyprinus carpio). The disease caused by this virus is characterized by tissue necrosis and petechial hemorrhages. However, the pathogenesis of SVCV infection remains poorly understood. Pyroptosis, a recently … Read more

CAR-ving a Path: Metalloprotease-Engineered CAR T Cells Tunnel through Solid Tumors

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Cancer Immunol Res. 2025 Oct 8:OF1-OF2. doi: 10.1158/2326-6066.CIR-25-1097. Online ahead of print. ABSTRACT Overcoming the physical barriers of the tumor microenvironment remains a major obstacle for chimeric antigen receptor (CAR) T-cell therapy in solid tumors. In this issue, Van Pelt and colleagues show that engineering GD2-targeting CAR T cells to express matrix metalloproteinase 7 and … Read more

A mother’s touch: microbial guardians of early immune imprinting. Melody Y Zeng

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Trends Immunol. 2025 Oct 6:S1471-4906(25)00227-3. doi: 10.1016/j.it.2025.09.008. Online ahead of print. ABSTRACT The evolution of the fetal immune system within the womb is a delicate balancing act: it is trained to not reject maternal antigens, while equipping itself with ‘learned’ immunity to survive and thrive in the outside world. In this opinion article, we propose … Read more

Human CD24+CD38+ regulatory B cells promote Pro-resolving Macrophage Function through the synergistic effect of IL-10 and PD-L1​Elaheh Dalir Abdolahinia on 8 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 7:qiaf141. doi: 10.1093/jleuko/qiaf141. Online ahead of print. ABSTRACT Regulatory B cells (Bregs), specifically the CD24⁺CD38⁺ phenotype, are known for their capacity to reduce inflammation by releasing interleukin 10(IL-10). However, their potential role in regulating inflammation through macrophage differentiation is not well understood. This study investigates how CD24⁺CD38⁺ regulatory B cells … Read more

Unlocking IL-18: A hidden key in cancer immunity. Shima Sepehri-Manesh

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Semin Immunol. 2025 Oct 6;80:101997. doi: 10.1016/j.smim.2025.101997. Online ahead of print. ABSTRACT The IL-1 family comprises 11 cytokines, including IL-1α, IL-1β, IL-1 receptor antagonist (IL-1Ra), IL-18, IL-33, and IL-36 cytokines to IL-37 and IL-38, that modulate innate immune system activity. In addition to their role in innate immunity, IL-1 family members can activate and enhance … Read more

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