inmunoadmin

Mechanisms of Immune Suppression in Sepsis/Shock: One investigator’s/lab group’s experience (SLB 2024 Legacy Award Presentation)​Alfred Ayala on 24 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 24:qiaf108. doi: 10.1093/jleuko/qiaf108. Online ahead of print. ABSTRACT When I think about scientific/professional “legacy”, for me there are at least 3 areas to consider: 1) the actual scientific legacy you (and your lab members) have contributed to; 2) the people you have touched and how they touch you in this … Read more

Dupilumab-induced Eosinophilic Granulomatosis with Polyangiitis Complicated by Peripheral Neuropathic Pain: a Case Report and Literature Review

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J Clin Immunol. 2025 Jul 24;45(1):114. doi: 10.1007/s10875-025-01914-x. ABSTRACT PURPOSE: Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a rare vasculitis characterized by increased eosinophils in human tissues and peripheral blood. In this case, we present a 53-year-old female patient with EGPA. By this case and literature review, we want to explain the early manifestations, diagnosis, and … Read more

Self‐Antigens Select B Cells: A New Perspective on B Cell Selection and Function. [[{“value”:”Mike Aoun, Rikard Holmdahl”}]]

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Positively selected autoreactive B cells (C1-Bsup) specific for collagen type II (COL2) suppress inflammation, while pathogenic COL2-specific plasma cells (CB20 clone) drive it. The balance between suppressive and pathogenic autoreactive responses governs tissue homeostasis. ABSTRACT The adaptive immune system is shaped by self-recognition, creating a paradox where autoreactivity is essential for immune regulation, yet implicated … Read more

Glucocorticoid-induced Pneumocystis pneumonia mice developed immune reconstitution inflammatory syndrome after glucocorticoid withdrawal

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J Immunol. 2025 Jul 23:vkaf071. doi: 10.1093/jimmun/vkaf071. Online ahead of print. ABSTRACT Mortality from Pneumocystis pneumonia (PCP) continues to increase among non-human immunodeficiency virus (HIV) patients. Previous studies have reported that a considerable proportion of patients experience deterioration of their disease when glucocorticoids or other immunosuppressants are withdrawn. However, the underlying mechanisms responsible for this … Read more

Refined cell transfer model reveals roles for Ascl2 and Cxcr3 in splenic localization of mouse NK cells during virus infection

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J Immunol. 2025 Jul 22:vkaf122. doi: 10.1093/jimmun/vkaf122. Online ahead of print. ABSTRACT Cell transfer experiments complement the rigorous investigation of antiviral and antitumor functions of natural killer (NK) cells. Success in these endeavors is enhanced by expansion of small numbers of input NK cells driven by viral antigens or homeostatic proliferation in immunodeficient hosts. In … Read more

Decreased HLA-DR+CD3+ T cells three months after allogeneic stem cell transplantation predict severe chronic GvHD and transplant-related mortality​Stefan Koeck on 22 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 22:qiaf106. doi: 10.1093/jleuko/qiaf106. Online ahead of print. ABSTRACT Chronic Graft versus Host Disease (cGvHD) is a major late determinant of transplant related mortality (TRM) after allogeneic stem cell transplantation (HSCT). We investigated the predictive value of peripheral blood activated HLA-DR+CD3+ T cells as a novel biomarker. In total, 107 patients … Read more

An IL-15-modified NKp30×HER2 trispecific NK cell engager enhances NK cell activation and tumor cell killing​Yaping Cheng on 22 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 22:qiaf107. doi: 10.1093/jleuko/qiaf107. Online ahead of print. ABSTRACT Natural killer (NK) cells represent a promising effector population for tumor immunotherapy. Conventional NK cell engagers (NKCEs), primarily targeting CD16a, show efficacy but face limitations due to receptor polymorphisms and off-target toxicity. Here, we report the development and characterization of a novel … Read more

Gut microbiota-host post-translational modification axis in immunometabolic diseases. Shuo Li

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Trends Immunol. 2025 Jul 21:S1471-4906(25)00163-2. doi: 10.1016/j.it.2025.06.006. Online ahead of print. ABSTRACT Communication between the gut microbiota and host post-translational modifications (PTMs) has been extensively characterized, and recent evidence delineates a functionally integrated gut microbiota-host PTM axis. This axis is not only essential for maintaining metabolism homeostasis but also plays diverse roles in regulating disease … Read more

Microbial dysbiosis sculpts a systemic ILC3/IL-17 axis governing lung inflammatory responses. Ahmed Kabil

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Mucosal Immunol. 2025 Jul 20:S1933-0219(25)00073-X. doi: 10.1016/j.mucimm.2025.07.002. Online ahead of print. ABSTRACT Advancements in vaccination and sanitation have significantly reduced the prevalence and burden of infectious diseases; however, these benefits have coincided with a marked rise in autoimmune and allergic disorders. Recent studies have investigated these linked trends through the lens of host-microbiome alterations, proposing … Read more

Uncovered role of Th9 and IL-9 in rheumatoid arthritis: Current status and future directions. Jiajie Tu

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Semin Immunol. 2025 Jul 21;79:101979. doi: 10.1016/j.smim.2025.101979. Online ahead of print. ABSTRACT Early studies on T helper (Th) 9 cells and their specific cytokine IL-9 mainly focused on the field of allergic diseases. In addition to pathological studies, IL-9 can also affect the normal development and various functions of T cells and B cells. In … Read more

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