inmunoadmin

Microglia in systemic neuroimmune communication: functions beyond phagocytosis. Anabella Ayelen Di Pietro

by

Trends Immunol. 2026 Jan 7:S1471-4906(25)00310-2. doi: 10.1016/j.it.2025.12.002. Online ahead of print. ABSTRACT Bidirectional crosstalk between the immune and nervous systems, via ‘neuroimmune circuits’, regulates homeostatic and inflammatory responses essential for health. Microglia, long-lived brain macrophages, act as key hubs integrating immune signals into coordinated brain responses by shifting into distinct functional states in response to … Read more

Phase II trial of interleukin-12 followed by interferon alfa-2b in patients with metastatic malignant melanoma: Results from CALGB 500001 (Alliance)

by

Cancer Immunol Res. 2026 Jan 8. doi: 10.1158/2326-6066.CIR-25-0880. Online ahead of print. ABSTRACT The ability of interleukin-12 (IL-12) to stimulate production of interferon gamma (IFN-γ) suggested it might improve the efficacy of low dose interferon alpha (IFN-α). In this phase II trial, patients with metastatic malignant melanoma were administered recombinant human (rh) IL-12 followed by … Read more

Association between absolute blood eosinophil count and carotid plaque in the Multi-Ethnic Study of Atherosclerosis (MESA)​Nyla E Mathis on 8 de January de 2026 at 11:00

by

J Leukoc Biol. 2026 Jan 8:qiag003. doi: 10.1093/jleuko/qiag003. Online ahead of print. ABSTRACT Prior studies have demonstrated associations between eosinophil activation products and incident stroke. We investigated whether circulating eosinophil concentration is associated with imaging markers of atherosclerotic cardiovascular disease (ASCVD), analyzing two arterial beds (carotid artery plaque [CAP] and coronary artery calcium [CAC]) in … Read more

The selective estrogen receptor modulator bazedoxifene affects the metabolism and functions of human neutrophils​Elena Lonina on 8 de January de 2026 at 11:00

by

J Leukoc Biol. 2026 Jan 8:qiag007. doi: 10.1093/jleuko/qiag007. Online ahead of print. ABSTRACT Bazedoxifene is a selective estrogen receptor modulator that is prescribed to menopausal women to treat symptoms of estrogen deficiency. Furthermore, bazedoxifene is being considered for cancer therapeutics due to its ability to block IL-6 signaling. However, various selective estrogen receptor modulators have … Read more

SARS‐CoV‐2 mRNA Vaccination Leads to Transient Humoral and B Cell Bystander Responses in Adults. [[{“value”:”Lisan H. Kuijper, Laura Y. L. Kummer, Laura Fernandez Blanco, Karlijn van der Straten, Mathieu A. F. Claireaux, Amélie V. Bos, Miranda C. Dieker‐Meijer, Tineke Jorritsma, Mariël C. Duurland, Maurice Steenhuis, Juan J. Garcia Vallejo, Koos P. J. van Dam, Eileen W. Stalman, Luuk Wieske, Sander W. Tas, Laura Boekel, Gert‐Jan Wolbink, Theo Rispens, Taco W. Kuijpers, Filip Eftimov, Marit J. van Gils, Anja ten Brinke, S. Marieke van Ham, T2B! immunity against SARS‐CoV‐2 study group”}]]

by

SARS-CoV-2 mRNA vaccination triggers bystander activation of B cells, transiently increasing antibody levels after the first vaccination against influenza, RSV, and tetanus. Reactivation of B cell responses also occurred, where (CD11c+) MBC and DN3 are expanded after SARS-CoV-2 mRNA vaccination, independent of antigen exposure. ABSTRACT After antigen encounter, long-lived antibody-secreting cells (ASC) secrete high-affinity circulating … Read more

IL-10R inhibition induces neutrophil tumoricidal activity

by

Cancer Immunol Res. 2026 Jan 7. doi: 10.1158/2326-6066.CIR-25-0834. Online ahead of print. ABSTRACT While the role of neutrophils in modulating antitumor T cell responses has been extensively studied, their direct effects on tumor cells remains less well understood. In this study, we investigated whether neutrophils have the capacity to directly kill tumor cells independently of … Read more

CD101 – a versatile molecule associated with immunoregulatory and anti-microbial functions​Jochen Mattner on 6 de January de 2026 at 11:00

by

J Leukoc Biol. 2026 Jan 5:qiaf189. doi: 10.1093/jleuko/qiaf189. Online ahead of print. ABSTRACT CD101 is a disulfide-linked immunoglobulin-like glycoprotein with a unique glutamine-tryptophan-isoleucine (EWI) sequence motif. Allelic variations within the Cd101 gene can influence CD101 expression and function of different myeloid cell and T lymphocyte populations. CD101 serves also as maturation marker for neutrophils and … Read more

deneme bonusu veren siteler - canlı bahis siteleri - casino siteleri casino siteleri deneme bonusu veren siteler canlı casino siteleri 301 Moved Permanently

301 Moved Permanently

nginx/1.24.0 (Ubuntu)