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Loss of NF-κB inducing Kinase (NIK) affects eosinophilopoiesis in a murine model of Hypereosinophilic Syndrome​Brie Trusiano on 27 de February de 2026 at 11:00

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J Leukoc Biol. 2026 Feb 27:qiag028. doi: 10.1093/jleuko/qiag028. Online ahead of print. ABSTRACT NF-κB inducing kinase (NIK), an upstream regulator of the noncanonical NF-κB signaling pathway, is implicated in the development of Hypereosinophilic-like syndrome (HES) in mice. HES in human patients is defined by 1.5×109 cells/L circulating in the blood with end-organ infiltration and resultant … Read more

Constitutive STAT3 signaling, in comparison to STAT5, enhances CAR T cell efficacy and lowers systemic toxicity

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Cancer Immunol Res. 2026 Feb 27. doi: 10.1158/2326-6066.CIR-25-0611. Online ahead of print. ABSTRACT Providing cytokine signaling is a key strategy to boost the efficacy of chimeric antigen receptor (CAR) T cell therapy. However, the individual roles of key downstream mediators, STAT3 and STAT5, remain incompletely understood. In this study, we engineered CAR T cells to … Read more

Integrated Single-Cell Profiling Reveals Dichotomous NK Cell Populations Associated with Immunosuppression in Solid Tumors

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Cancer Immunol Res. 2026 Feb 27. doi: 10.1158/2326-6066.CIR-25-1229. Online ahead of print. ABSTRACT Natural killer (NK) cells represent key effectors of antitumor immunity, yet emerging evidence highlights populations with distinct roles in cancer. Despite such expanded diversity within the NK cell repertoire, we lack an understanding of how this heterogeneity impacts immune responses and downstream … Read more

Class A Scavenger receptors promote tumor progression and induce a unique macrophage phenotype in a mouse model of spontaneous breast cancer​Behjatolah Monzavi-Karbassi on 27 de February de 2026 at 11:00

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J Leukoc Biol. 2026 Feb 26:qiag026. doi: 10.1093/jleuko/qiag026. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) are a critical component of the immune response to cancer, and their role in modulating cancer progression is well-recognized. Macrophages express pattern-recognition receptors, including Class A Scavenger Receptors (SR-A), which are pivotal in regulating macrophage activation and polarization into … Read more

Emerging roles of IL-9 and Th9 cells in respiratory viral illnesses. Jyotsna Dandotiya

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Semin Immunol. 2026 Feb 24;81:102017. doi: 10.1016/j.smim.2026.102017. Online ahead of print. ABSTRACT Upon antigenic stimulation and cytokine cues, CD4⁺ T cells differentiate into specialized helper subsets, giving rise to Th1, Th2, Th9 and Th17 cell lineages. These subsets orchestrate distinct immune functions that protect the host but can also drive immunopathology when dysregulated. The classical … Read more

Curbing Autoimmunity: A New Fab Fragment Targeting CD40‐CD40L Halts B‐Cell Activation and Differentiation. [[{“value”:”Kathrine Pedersen, Kenneth Green, Emil L. Kristoffersen, Thea Schinkel, Annette G. Hansen, Yaseelan Palarasah, Anne B. Rovsing, Ebbe S. Andersen, Julián Valero, Laia Civit, Nick S. Laursen, Anne Troldborg, Søren E. Degn, Steffen Thiel”}]]

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The CD40-CD40L pathway is often dysregulated in B-cell-driven autoimmune diseases, making the development of CD40L inhibitors a promising therapeutic approach in managing autoimmune responses. We developed an inhibitory anti-CD40L Fab fragment, Fab20, and demonstrated that Fab20 effectively suppresses B-cell proliferation, differentiation, and antibody production in vitro. Made with Biorender. ABSTRACT Dysregulation of the CD40-CD40L axis … Read more

Loss of miR-29a/b1 cluster reprograms the tumor microenvironment and contributes to immunosuppression in lung cancer

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Cancer Immunol Res. 2026 Feb 25. doi: 10.1158/2326-6066.CIR-25-1060. Online ahead of print. ABSTRACT Immune checkpoint inhibitors (ICI), including those that block PD-1/PD-L1, have revolutionized therapy for patients with non-small cell lung cancer. However, most patients demonstrate no clinical benefit or acquire resistance, even when tumors express PD-L1. This highlights the critical need to dissect tumor … Read more

Intra-tumoral tertiary lymphoid structures characterized by a B cell-related signature elicit antitumor effect through HAPLN3 in hepatocellular carcinoma

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Cancer Immunol Res. 2026 Feb 25. doi: 10.1158/2326-6066.CIR-25-0758. Online ahead of print. ABSTRACT The existence of intra-tumoral tertiary lymphoid structures (TLSs) has been reported to be correlated with reduced recurrence of hepatocellular carcinoma (HCC). However, the cellular characteristics and driving mechanism of TLSs in HCC remain largely unknown. In this study, we compared clinical outcomes … Read more

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