A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors
Cancer Immunol Res. 2026 Jun 2;14(6):899. doi: 10.1158/2326-6066.CIR-14-6-WWR. NO ABSTRACT PMID:42226639 | DOI:10.1158/2326-6066.CIR-14-6-WWR
inmunoadmin
Clinical Cognition and Practice in Anti-Interferon-γ Autoantibody-Associated Immunodeficiency Syndrome
J Clin Immunol. 2026 Jun 2. doi: 10.1007/s10875-026-02039-5. Online ahead of print. ABSTRACT Adult-onset immunodeficiency syndrome mediated by anti-interferon-gamma autoantibody (AIGA) is a rare disorder that has garnered increasing recognition in recent years. The condition is most prevalent among adults in Southeast Asia. It is characterized by recurrent disseminated opportunistic infections, frequently involving multiple organ … Read more
Cover Story: Eur. J. Immunol. 6’26.
Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more
Issue Information: Eur. J. Immunol. 6’26.
European Journal of Immunology, Volume 56, Issue 6, June 2026.
Managing Autofluorescence in Spectral Flow Cytometry for Macrophage Identification in the Liver. [[{“value”:”Sabine Daemen, Tuneille I. Adelaar, Panos Barlampas, Xiaodi Zhang, Casper G. Schalkwijk, Kristiaan Wouters”}]]
Autofluorescence in liver tissue is heterogeneous and dynamically altered during metabolic liver disease, complicating spectral flow cytometry analysis. We provide a structured framework for identifying and handling condition-dependent autofluorescence, demonstrating that inadequate autofluorescence correction biases macrophage quantification and subset resolution in complex liver samples. ABSTRACT Autofluorescence (AF) in biological tissues arises from the natural emission … Read more
Characterization of Harderian Gland‐Derived Plasma Cells in Chicken. [[{“value”:”D. von La Roche, I. Naumann, E. Szőcs, V. Halasy, M. Kohn, B. Kaspers, N. Nagy, S. Härtle”}]]
An isolation protocol for plasma cells (PC) from the chicken Harderian gland (HG) was established, and analyses of PCs revealed a FSChigh/CD45med/sIgpos/CD57pos/CXCR4high/TACIlow phenotype. Presence of CXCL12 and BAFF around HG PCs suggests a contribution of CXCL12–CXCR4 and BAFF–TACI to PC localization and survival. ABSTRACT Due to fundamental differences in B cell development between birds and … Read more
Sex-specific in utero reprogramming of lung immunity. Anthony Maxwell
Mucosal Immunol. 2026 May 31:100352. doi: 10.1016/j.mucimm.2026.100352. Online ahead of print. ABSTRACT Lung mucosal immunity must balance effective antimicrobial defense with tightly controlled inflammatory responses to maintain pulmonary homeostasis. Although sex differences in respiratory disease susceptibility are well documented, the developmental origins of these differences and their modulation by prenatal environmental exposures remain poorly defined. … Read more
The Role of B cells in Idiopathic Inflammatory MyopathiesRaúl F Reyes-Huerta on 1 de June de 2026 at 10:00
J Leukoc Biol. 2026 Jun 1:qiag071. doi: 10.1093/jleuko/qiag071. Online ahead of print. ABSTRACT Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune disorders characterized by skeletal muscle inflammation and systemic immune activation. Although traditionally viewed as T cell-driven diseases, recent evidence suggests that B lymphocytes may also contribute to disease mechanisms through both antibody-dependent … Read more
FXII Frameshift Variant Does Not Cause Hereditary Angioedema with Normal C1 Inhibitor
J Clin Immunol. 2026 Jun 1;46(1):57. doi: 10.1007/s10875-026-02041-x. NO ABSTRACT PMID:42223816 | DOI:10.1007/s10875-026-02041-x
Fibrinogen and lipopolysaccharide promote TLR4-dependent glucocorticoid resistance in airway mycosis-driven allergic airway disease. Y Zeng
Mucosal Immunol. 2026 May 30:100354. doi: 10.1016/j.mucimm.2026.100354. Online ahead of print. ABSTRACT Glucocorticoid-refractory asthma is a severe disease type linked to both T helper type 2 (T2) high and T2 low, neutrophil-high asthma endotypes, but the mechanisms governing glucocorticoid resistance are largely unknown. We show that glucocorticoid-resistant mouse allergic airway disease is linked to airway … Read more