inmunoadmin

Loss of Neutrophils and SLPI Reshapes Early Mucosal Inflammatory Responses During Intranasal Vaccination. [[{“value”:”Oktawia Osiecka, Mariia Tyshchenko, Ivan Sinkevich, Natalia Pocałuń, Joanna Cichy, Jakub M. Kwiecinski, Ewa Oleszycka, Mieszko M. Wilk”}]]

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Intranasal vaccination induces pulmonary neutrophil accumulation and SLPI release, accompanied by changes in soluble mediators associated with tissue remodelling, coagulation, and total IgA. ABSTRACT Vaccines delivered via the nasal route have attracted increasing attention for their capacity to engage the mucosal immune system at the primary site of pathogen entry. However, the early innate mechanisms … Read more

B‐Cell Remodeling and Regulatory Phenotypes During Acute COVID‐19 Are Unaffected by Polyclonal Anti‐SARS‐CoV‐2 Antibody XAV‐19. [[{“value”:”Nicolas Degauque, Richard Danger, Hoa Le Mai, Marion Cadoux, Thi‐Van‐Ha Nguyen, Gaëlle Tilly, François Raffi, Thomas Guimard, Karine Lacombe, Didier Laureillard, Laurent Hocqueloux, Vincent Dubee, Florence Ader, Cynthia Fourgeux, Jérémie Poschmann, Bernard Vanhove, Odile Duvaux, Benjamin Gaborit, Sophie Brouard, POLYCOR study group”}]]

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SARS-CoV-2 infection drives transient B-cell remodeling toward an activated, regulatory-like phenotype. In this randomized sub-study, the polyclonal neutralizing antibody XAV-19 did not detectably alter B-cell phenotype, transcriptome, or function relative to placebo, indicating that passive polyclonal therapy preserves B-cell homeostasis during acute COVID-19. ABSTRACT Regulatory B cells (Bregs) are emerging as pivotal modulators of immune … Read more

Diminished FcγRIIa expression reduces antibody-mediated phagocytosis by low-density neutrophils in obesity​Carlos Blanco-Camarillo on 15 de September de 2026 at 10:00

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J Leukoc Biol. 2026 Sep 15:qiag128. doi: 10.1093/jleuko/qiag128. Online ahead of print. ABSTRACT Obesity is a chronic inflammatory disease associated with an increased risk of various medical complications, including cardiovascular problems, diabetes, and infectious diseases. A central element of the immune system associated with inflammation and antimicrobial function is neutrophils. Recently, distinct neutrophil subpopulations have … Read more

FasL-mediated death of activated intratumoral T cells drives secondary resistance to cancer immunotherapy

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Cancer Immunol Res. 2026 Sep 15. doi: 10.1158/2326-6066.CIR-25-1567. Online ahead of print. ABSTRACT Cancer progression following an initial response to immunotherapy (secondary resistance; 2°R) is a major and poorly understood problem. We treated mice bearing B16 melanoma with a combination of a regulatory T cell (Treg) depleting, non-IL-2 blocking antibody (anti-CD25NIB) and an autologous cancer … Read more

Arid2 regulates peripheral B cell maturation and germinal-center responses in vivo

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J Immunol. 2026 Aug 29;215(9):vkag247. doi: 10.1093/jimmun/vkag247. ABSTRACT SWI/SNF chromatin remodeling complexes regulate gene expression during development and differentiation. These complexes exist in distinct forms, including the polybromo-associated BAF (PBAF) complex, defined by the ARID2 subunit. ARID2 is frequently mutated in B cell leukemias, but its role in normal B cell development remains unknown. Using … Read more

Scopolamine ameliorates psoriasis by blocking M1 receptor-mediated IL-23 production in dendritic cells

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J Immunol. 2026 Aug 29;215(9):vkag179. doi: 10.1093/jimmun/vkag179. ABSTRACT Psoriasis is a chronic inflammatory skin disease involving intricate neuroimmune crosstalk. However, the specific mechanisms and therapeutic targets remain elusive. In this study, a pilot clinical trial demonstrated that intravenous scopolamine, a muscarinic receptor antagonist, significantly ameliorated skin lesions in psoriasis patients. Consistently, scopolamine reduced inflammation in … Read more

Metabolite-Mediated Crosstalk Between Neutrophils, Commensal Bacteria, and Dendritic Cells Is Associated with Intestinal Immune Responses​Sun-Hwa Kim on 15 de September de 2026 at 10:00

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J Leukoc Biol. 2026 Sep 15:qiag123. doi: 10.1093/jleuko/qiag123. Online ahead of print. ABSTRACT The intestinal immune system relies on coordinated interactions between innate immune cells and commensal bacteria. How metabolites integrate host-microbe communication in the gut remains incompletely understood. Using neutrophil activation assays, bacterial chemotaxis analysis, short-chain fatty acid profiling, and imaging of inflamed intestinal … Read more

The light side of mast cell degranulation: delivering macrophage repair through molecular condensates​Alejandro Schcolnik-Cabrera on 15 de September de 2026 at 10:00

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J Leukoc Biol. 2026 Sep 15:qiag125. doi: 10.1093/jleuko/qiag125. Online ahead of print. ABSTRACT Mast cell (MC) degranulation is commonly viewed as the rapid release of preformed inflammatory mediators into the extracellular environment. In a recent study published in the Journal of Experimental Medicine, Salm et al. described a more spatially controlled form of MC communication … Read more

Spatially instructed checkpoints in antitumor NK cell immunity. Ruifeng Wang

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Trends Immunol. 2026 Sep 14:S1471-4906(26)00228-0. doi: 10.1016/j.it.2026.08.012. Online ahead of print. ABSTRACT Natural killer (NK) cell immunotherapies remain less effective in solid tumors than in hematologic malignancies. Poor infiltration, checkpoint engagement, and metabolic stress contribute, but these mechanisms often operate within spatially organized niches. We develop the concept of spatially instructed checkpoints: inhibitory programs locally … Read more

Papaverine ameliorates psoriasis-like skin inflammation by regulating immune cell differentiation and RAGE-S100A7 axis in an imiquimod-induced murine model

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J Immunol. 2026 Aug 29;215(9):vkag233. doi: 10.1093/jimmun/vkag233. ABSTRACT Psoriasis is a chronic, immune-mediated inflammatory skin disease affecting at least 2% of the global population. Papaverine, an alkaloid with known anti-inflammatory, anti-cancer, and RAGE-antagonistic properties, has not been previously evaluated for anti-psoriatic activity. This study investigated the protective effects and mechanisms of papaverine in an imiquimod … Read more

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