inmunoadmin

Low‐Input Assay for Transposase‐Accessible Chromatin Identifies Epigenetic Signatures of Liver Group 1 Innate Lymphoid Cells. [[{“value”:”Kevin Schmid, Robin P. Schenk, Gabriela M. Wiedemann”}]]

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Assessing chromatin accessibility in rare cell populations within tissue remains a key challenge. To address this, we present a low-input ATAC workflow optimized for liver ILCs. The protocol is validated across cell numbers, Tn5 ratios, and library preparation steps and unveils unique epigenetic features of liver NK cells and ILC1s.

Potential impact of long-read sequencing on complement-mediated diseases. Sarah M Carpanini

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Trends Immunol. 2025 Oct 2:S1471-4906(25)00225-X. doi: 10.1016/j.it.2025.09.006. Online ahead of print. ABSTRACT The complement genes harbour genetic variants that affect numerous diseases; however, these genes are notoriously repeat-heavy, and these repeat regions are largely unexplored for disease-relevant genetic variation. Elucidating these ‘dark’ regions is now possible using long-read sequencing (LRS), enabling identification of novel disease-relevant … Read more

Impact of absent in melanoma 2 on head and neck squamous cell carcinoma development

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J Immunol. 2025 Oct 3:vkaf224. doi: 10.1093/jimmun/vkaf224. Online ahead of print. ABSTRACT Head and neck squamous cell carcinoma (HNSCC) constitutes 90% of head and neck cancers. HNSCC development is linked to chronic inflammation, while established HNSCC tumors are often immune suppressive. However, both occur through mechanisms that are not fully understood. The cytosolic double-stranded DNA … Read more

Diabetes and insulin resistance alters ligamentum flavum-derived fibroblast responses in an AKT2-dependent manner

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J Immunol. 2025 Oct 3:vkaf233. doi: 10.1093/jimmun/vkaf233. Online ahead of print. ABSTRACT Fibroblasts participate in inflammatory responses and play a critical role in the switch from acute to persistent inflammation. Whether fibroblast responses are modulated by signals from their microenvironment is not well established. Insulin signaling and insulin resistance modulate responsiveness of innate immune cells … Read more

COVID-19 and inflammatory bowel disease – what to know

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Curr Opin Immunol. 2025 Sep 30;97:102661. doi: 10.1016/j.coi.2025.102661. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) represents a chronic inflammation of the gastrointestinal tract that arises from a complex interplay between a dysregulated immune response in genetically predisposed individuals. IBD can further be classified into its two main subtypes, Crohn’s disease and ulcerative colitis. … Read more

Reovirus oncolysis and the next frontiers for this unique oncoviral immunotherapy. Negar Sharifi

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Semin Immunol. 2025 Sep 30;80:101995. doi: 10.1016/j.smim.2025.101995. Online ahead of print. ABSTRACT Reovirus is one of the most clinically investigated oncolytic viruses, with over 50 clinical trials and more than 1700 patients treated to date. Although it has yet to achieve complete regulatory approval, reovirus remains a promising oncolytic virus candidate for cancer immunotherapy due … Read more

Dynamic control of autoreactive B cells from spontaneous germinal centers

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J Immunol. 2025 Oct 1:vkaf223. doi: 10.1093/jimmun/vkaf223. Online ahead of print. ABSTRACT Systemic lupus erythematosus is characterized by activation of many self-reactive B cell clones that produce autoantibodies. This can be modeled using mixed bone marrow chimeras, where autoreactive 564Igi B cells initiate autoimmunity that spreads to wild-type (WT) B cells. The mechanisms controlling the … Read more

Antibody Mediated Inhibition of HLA/LILR Interactions Breaks Innate Immune Tolerance and Induces Antitumor Immunity

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Cancer Immunol Res. 2025 Oct 1. doi: 10.1158/2326-6066.CIR-25-0343. Online ahead of print. ABSTRACT Immune check-point blockade for the treatment of malignancies has been focused on reversing inhibitory pathways in T lymphocytes. Natural killer (NK) cells are a potent innate defense against tumors and virally infected cells, but their therapeutic manipulation for anti-cancer immunity has been … Read more

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