inmunoadmin

Altered B cell metabolic pathways characterize type 1 diabetes progression

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J Immunol. 2025 Dec 27:vkaf330. doi: 10.1093/jimmun/vkaf330. Online ahead of print. ABSTRACT Type 1 diabetes (T1D) results from immune-mediated destruction of pancreatic beta cells. B cells serve as critical antigen-presenting cells whose autoreactive specificities drive disease progression. Conversely, IL-10 producing regulatory B cells (Bregs) exert immunosuppressive functions and have been shown to protect against autoimmunity … Read more

Age-Related Patterns of Type II Interferon Immunity: Implications for Intramacrophagic Infections and MSMD Diagnosis During Childhood

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J Clin Immunol. 2025 Dec 26. doi: 10.1007/s10875-025-01955-2. Online ahead of print. ABSTRACT Type II interferon (IFN) immunity is crucial for controlling intramacrophagic infections, driven by the interaction between innate immunity (macrophage-derived IL-12) and adaptive immunity (Th-derived IFN-γ). This study examines the maturation of type II IFN immunity in 55 healthy children (ages 1-18) to … Read more

The Distinct Monocyte Subsets and Intercellular Communication in Primary Sjögren’s Syndrome Revealed by Single-Cell RNA Sequencing

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J Clin Immunol. 2025 Dec 27. doi: 10.1007/s10875-025-01974-z. Online ahead of print. ABSTRACT OBJECTIVE: The presence of unique monocyte subsets and sub-populations plays a significant role in the onset and progression of rheumatic diseases. This study aimed to characterize variations in monocyte subsets and sub-populations and functional roles in patients with primary Sjögren’s syndrome (pSS) … Read more

Vimentin recognizes African swine fever virus genomic DNA and triggers inflammatory responses by activation of NLRP3 inflammasome

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J Immunol. 2025 Dec 25:vkaf315. doi: 10.1093/jimmun/vkaf315. Online ahead of print. ABSTRACT Previous studies have reported that African swine fever virus (ASFV) infection can induce inflammatory responses through the activation of the NLRP3 inflammasome, resulting in the release of IL-1β and the cleavage of gasdermin D. However, the mechanism by which pattern recognition receptors in … Read more

Highly efficient and low-cost single-cell culture platform for unbiased analysis of human memory B cell repertoire and antibody discovery

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J Immunol. 2025 Dec 25:vkaf305. doi: 10.1093/jimmun/vkaf305. Online ahead of print. ABSTRACT The SARS-CoV-2 pandemic underscored the need for innovative approaches to study humoral immunity and isolate monoclonal antibodies (mAbs) with diagnostic and therapeutic potential. Current methods for repertoire analysis at the clonal level require large-scale recombinant mAb production, limiting accessibility and delaying functional insight. … Read more

Wheat fiber-induced peripheral regulatory T-cells suppress development of colitis. Seong-Eun G Kim

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Mucosal Immunol. 2025 Dec 22:S1933-0219(25)00139-4. doi: 10.1016/j.mucimm.2025.12.003. Online ahead of print. ABSTRACT Reduced dietary fiber intake is associated with, and may have contributed to, the post-mid-20th century increase in immune-mediated chronic inflammatory diseases, including inflammatory bowel disease (IBD). Reduced fiber intake has resulted, in part, from increased consumption of highly refined foods including those made … Read more

The Predictive Value of Neutrophil Extracellular Trap-Related Risk Score in Prognosis and Tertiary Lymphoid Structure Features of Lung Adenocarcinoma Patients​Zhe Wang on 24 de December de 2025 at 11:00

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J Leukoc Biol. 2025 Dec 24:qiaf182. doi: 10.1093/jleuko/qiaf182. Online ahead of print. ABSTRACT Neutrophil extracellular traps (NETs) have been increasingly recognized as important modulators of tumor immunity. In this study, we investigated the prognostic significance of NETs-related genes expression and their impact on tertiary lymphoid structures (TLSs) in lung adenocarcinoma (LUAD). Using transcriptomic data from … Read more

Targeting CaMKIIδ Overcomes Therapy Resistance in Acute Myeloid Leukemia by Suppressing STAT3/CDK6/BCL-2 Survival Axis​Zhaoxing Wu on 24 de December de 2025 at 11:00

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J Leukoc Biol. 2025 Dec 24:qiaf184. doi: 10.1093/jleuko/qiaf184. Online ahead of print. ABSTRACT Relapse and therapy resistance remain major barriers to improving clinical outcomes in acute myeloid leukemia (AML), underscoring the need for actionable therapeutic targets. In this study, we identify calcium/calmodulin-dependent protein kinase II delta (CaMKIIδ) as a novel vulnerability in AML. CaMKIIδ is … Read more

Mapping the B-cell axis in Sjögren’s disease: repertoire, microenvironment, and potential routes to precision treatment

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Curr Opin Immunol. 2025 Dec 22;98:102712. doi: 10.1016/j.coi.2025.102712. Online ahead of print. ABSTRACT Sjögren’s disease (SjD) is a chronic autoimmune disorder in which sustained B-cell activation drives glandular injury and systemic complications. Epithelial stress and interferon tone amplify B-cell activating factor (BAFF)-dependent survival, skewing selection toward autoreactive clones in both glands and blood. In addition, … Read more

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nginx/1.24.0 (Ubuntu)