Lin Wang IntroductionLocal estrogen is widely used to improve vaginal mucosal status and relieve menopausal urogenital symptoms in patients with pelvic organ prolapse (POP), yet clinical outcomes are inconsistent. This creates an urgent need to clarify the tiss…
ObjectiveTo describe short-term clinical outcomes and safety of tofacitinib in four patients with active ankylosing spondylitis (AS) using real-world data, and to explore dynamic changes in gut microbiota before and after treatment.MethodsFour patients…
Pelvic organ prolapse (POP) is a prevalent condition that significantly impairs women’s quality of life and is closely linked to dysregulated estrogen signaling. This review examines the mechanisms through which estrogen, acting via nuclear receptors (…
BackgroundColorectal cancer (CRC) has emerged as a growing global health challenge, while immunotherapy, particularly mRNA-based cancer vaccines, has emerged as a promising approach due to its ability to induce targeted immune responses with minimal sy…
Graves’ ophthalmopathy (GO), also known as thyroid eye disease (TED), is the most common extrathyroidal manifestation of Graves’ disease and a leading cause of visual morbidity. The disease primarily affects the orbital tissue and is characterized by i…
BackgroundThe Systemic Inflammatory Response Index (SIRI) is a promising inflammatory marker; however, the relationship between SIRI and latent tuberculosis infection (LTBI), as well as its association with mortality rates, remains unclear. The present…
