Yang Liu ObjectivesAcute ischemic events (AIE) constitute life-threatening complications of Takayasu arteritis (TAK). This study aimed to identify vascular, inflammatory and immune factors associated with concurrent AIE in TAK patients.MethodsWe conducted a 10-…
BackgroundPathological response after neoadjuvant chemotherapy is a key treatment milestone in osteosarcoma. We evaluated whether a rule-derived preoperative peripheral inflammatory-lymphocyte recovery phenotype constructed from routinely collected lab…
Extracellular vesicles (EVs) are membrane-bound particles secreted by diverse cell types and mediate intercellular communication through the transfer of proteins, RNAs, lipids, metabolites and other biomolecules. EVs participate in multiple physiologic…
Intervertebral disc degeneration (IVDD) is frequently implicated in low back pain (LBP), yet the severity of degeneration on imaging often fails to parallel pain intensity or functional limitation. Modic changes capture abnormal marrow signal at the di…
BackgroundNew pulmonary lesions arising during chemoimmunotherapy for non-small cell lung cancer (NSCLC) pose a common diagnostic dilemma because they may reflect tumor progression, infection, treatment-related inflammation, or other benign processes. …
Cells can produce various metabolites, and both immune cells and the immune microenvironment are profoundly influenced by these metabolites. By reshaping the metabolic state of immune cells via metabolites, the host immune response can be effectively r…
Cell death is a crucial mechanism by which radiotherapy eliminates tumor cells. Ferroptosis, characterized by intracellular iron overload and lipid peroxidation, represents a distinct form of programmed cell death. Recent research has demonstrated that…
Acute myeloid leukemia (AML) is a heterogeneously primary hematopoietic neoplasm characterized by uncontrolled proliferation of immature myeloid cells, which is characterized with poor outcomes. Despite tremendous advances in the treatment paradigm of …
Cellular & Molecular Immunology, Published online: 15 October 2024; doi:10.1038/s41423-024-01226-xImmunotherapy for glioblastoma: current state, challenges, and future perspectives
Leopard coral grouper (Plectropomus leopardus) is one of the most important cultured fish in the Pacific and Indian oceans. Vibrio harveyi is a serious pathogen causing serious skin ulceration and high mortality in P. leopardus. To gain more insight in…
