Tuina therapy alleviates knee osteoarthritis by modulating PI3K/AKT/mTOR-mediated autophagy: an integrated machine learning and in vivo rat study

BackgroundPrevious studies suggest that Tuina therapy may alleviate knee osteoarthritis (KOA) by modulating the PI3K/AKT/mTOR signaling pathway and autophagy. However, these findings require validation. This study investigated the effect of Tuina monot…

Lung cancer tumor immune microenvironment: analyzing immune escape mechanisms and exploring emerging therapeutic targets

Lung cancer is the most common malignant tumor in the world. Presently, there are still problems, including a high recurrence rate, resistance, and serious toxic side effects, even if conventional treatments like chemotherapy, radiotherapy, and targete…

Harnessing multi-omics and artificial intelligence: revolutionizing prognosis and treatment in hepatocellular carcinoma

BackgroundHepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, characterized by elevated mortality rates and heterogeneity. Despite advancements in treatment, the development of personalized therapeutic strategies for HCC remains …

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