Passenger lymphocyte syndrome following organ and stem cell transplantation: current insights and clinical implications

BackgroundPassenger lymphocyte syndrome (PLS) is an alloimmune complication of ABO-mismatched solid organ or hematopoietic stem cell transplantation characterized by the production of antibodies by donor-derived B lymphocytes against the recipient’s re…

Impact of preformed donor-specific anti-human leukocyte antigen antibodies on the clinical outcomes in pediatric liver transplantation patients: a retrospective cohort study

PurposeThe impact of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) in pediatric liver transplantation (LT) have been widely studied. The effect of preformed DSAs in pediatric LT is still controversial. This study aimed to evaluate…

Association of donor-specific antibodies with adverse outcomes in solid organ transplantation: A systematic review and meta-analysis of 69 studies

ImportancePreformed donor-specific antibodies (pre-DSAs) are a significant immunologic barrier in solid organ transplantation (SOT), yet their association with post-transplant outcomes lacks consensus, limiting standardized clinical management.Objectiv…

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