Acute graft-versus-host disease (aGVHD), particularly with gastrointestinal (GI) involvement, remains a life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT). Despite corticosteroids and ruxolitinib as first- and…
Brucellosis is a highly contagious zoonotic disease characterized by a non-specific clinical presentation and complex disease progression and outcome. Hemophagocytic lymphohistiocytosis (HLH) is an abnormal immune response syndrome marked by potentiall…
Mutations in the ELANE gene, which encodes neutrophil elastase, are known to cause cyclic neutropenia (CyN) and severe congenital neutropenia (SCN). Currently, targeting ELANE for insertion-deletion to trigger nonsense-mediated mRNA decay (NMD) may be …
BackgroundThe average movement of esophagus is about 0.15 to 0.4 cm radially and 0.3 to 0.9 cm in the superior-inferior during radiotherapy. Little study has reported giant shift of esophagus during neoadjuvant chemotherapy and immunotherapy.Case prese…
Primary central nervous system (CNS) T-cell lymphomas, such as anaplastic large-cell lymphoma (ALCL) with anaplastic lymphoma kinase (ALK) negativity, are relatively rare and aggressive. Despite the administration of high-dose methotrexate (HD-MTX) the…
Immune checkpoint inhibitors (ICIs) enhance antitumor immunity by blocking inhibitory immune signals, but can lead to immune-related adverse events (irAEs). Therefore, effective management of irAEs is crucial during ICI therapy. We report the case of a…
This is the case of a 41-year-old man who presented with blurred vision, unconsciousness, and fever with a positive Babinski sign on both sides. Blurred vision, unconsciousness, and fever are commonly seen in neurology and emergency settings, with a wi…
This report describes a 56-year-old female diagnosed with lymphoepithelioma-like carcinoma with carcinosarcoma of the endometrium (LELCCSE). She experienced vaginal bleeding and lower abdominal discomfort without any obvious cause following six years o…
Patients with advanced lung adenocarcinoma lacking driver gene mutations face the clinical dilemma of limited treatment options and poor prognosis in later-line therapy. Although immune checkpoint inhibitors (ICIs) combined with anti-angiogenic agents …
Synchronous multiple gastric cancers (SMGC) represent a rare clinical entity with no established treatment guidelines. We report a 76-year-old female with two synchronous poorly differentiated adenocarcinomas (dMMR/MSI-H phenotype) in the gastric lesse…
