BackgroundImmune checkpoint inhibitors (ICIs) can induce a broad spectrum of immune-related adverse events (irAEs), including rare fibroinflammatory autoimmune manifestations. IgG4-related disease (IgG4-RD) has only exceptionally been described followi…
BackgroundA subset of cancer patients receiving monoclonal antibody PD-1/PD-L1 inhibitors may develop immune checkpoint inhibitor (ICI)-related neurological complications, such as ICI-related myasthenia gravis(MG)-myositis overlap syndrome and ICI-rela…
Immune checkpoint inhibitors (ICIs) have revolutionized the management of gastric cancer; however, they can lead to rare immune-related adverse events (irAEs) affecting the urinary system. Herein, we report a case of non-bacterial cystitis complicated …
BackgroundEctopic hepatocellular carcinoma (EHCC) is an exceedingly rare malignancy characterized by its occurrence outside the liver without a detectable intrahepatic primary tumor. Owing to its rarity and the absence of standardized management guidel…
Immunoglobulin A nephropathy (IgAN) is one of the most common forms of primary glomerulonephritis and can lead to renal failure requiring renal replacement therapy via dialysis. Current research indicates that telitacicept, an APRIL and BAFF inhibitor,…
Hemophagocytic lymphohistiocytosis (HLH) is a disorder characterized by dysregulated immune activation triggered by various etiologies, leading to excessive inflammatory responses, cytokine storm, and subsequent organ dysfunction. While the presence of…
BackgroundOverlap between aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD) and anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is uncommon and may be difficult to recognize, especially when NMOSD i…
A 37-year-old non-Caucasian woman presented with a 2-year history of pruritic, concentric erythematous plaques refractory to multiple topical and systemic therapies. The clinical findings were highly suggestive of erythema gyratum repens (EGR), a rare …
Reactivation of Epstein-Barr virus (EBV) can lead to life-threatening complications beyond hemophagocytic lymphohistiocytosis (HLH). We report a case of severe EBV reactivation in a 24-year-old female. She had persistent high fever, severe leukopenia, …
BackgroundCeftriaxone-induced hemolytic crisis is a rare, rapid, and severe drug adverse reaction. Once diagnosed, immediate discontinuation of ceftriaxone is the preferred treatment, but death remains unavoidable in some severe cases. This study repor…
