PurposeDepression is acknowledged to correlate with the occurrence and progression of multiple cancers. However, no study has yet systematically complied depression-related genes to construct a prognostic signature for lung adenocarcinoma (LUAD).Method…
ObjectiveOsteoarthritis (OA) involves an inflammatory imbalance, yet key mediators and their interplay with potential therapeutics like artemisinin (ART) remain poorly understood. This study aimed to systematically investigate these relationships using…
ObjectiveTo compare pathological response and safety among three preoperative treatment regimens—chemotherapy alone, chemotherapy plus immunotherapy, and chemotherapy plus immunotherapy and targeted therapy—in gastric cancer undergoing D2 gastrectomy, …
BackgroundColorectal cancer (CRC) is characterized by high mortality. Zinc finger protein ZIC2 plays a dual role in various cancers; however, its clinical value of ZIC2 in CRC remains unclear.MethodsTCGA cohort data, GEO datasets (GSE39582 and GSE13955…
Recent advances in chimeric antigen receptor (CAR) T cell therapy have transformed the treatment landscape of multiple myeloma, yet almost all patients ultimately relapse. Chromosomal 1q gains are associated with a higher risk of disease progression an…
ObjectiveThe aim of this study was to assess the therapeutic effects and underlying mechanisms of Dahuang Gancao Dandelion Decoction (DGD-D) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in a mice model, with an emphasis on modulation…
BackgroundWhile SARS-CoV-2 vaccines are highly effective in healthy individuals, the magnitude and durability of humoral and cellular responses in patients with solid malignancies receiving chemotherapy remain understudied. Previous reports suggest tha…
Simple summaryCombinations of monoclonal antibodies that activate the immune system have been highly effective for treatment of melanoma that has spread (metastasized). Unfortunately, this type of immunotherapy treatment can trigger serious side effect…
