ObjectiveTo systematically evaluate the efficacy and safety of thymosin α1 combined with chemotherapy in the treatment of gastric cancer.MethodsA systematic search of 8 electronic databases was conducted to identify relevant RCTs. Meta-analysis was per…
Cancer evolves within tissue ecosystems in which innate immune surveillance and tumor-promoting inflammation jointly shape disease progression and therapeutic response. Innate receptors detect cellular stress, altered-self ligands, damaged-cell product…
Rheumatoid factor (RF), an autoantibody targeting IgG, is a key diagnostic marker of autoimmune diseases, especially rheumatoid arthritis (RA). In patients with RA, high RF titers have been reported to be associated with disease severity and may influe…
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a remarkably broad and heterogeneous autoantigen repertoire. While epitope spreading, aberrant B-cell activation, and molecular mimicry act in concert with defective a…
Rheumatoid arthritis (RA) is a systemic, chronic autoimmune disease. Based on the previous research results we conducted on the prevention of RA with Bifidobacterium animalis BD400, we generated a large longitudinal 16S rRNA sequencing dataset to chara…
Neutrophils are increasingly recognized as a heterogeneous lineage rather than a uniform population of short-lived innate effector cells. Low-density neutrophils (LDNs; often termed low-density granulocytes, LDGs) are operationally defined by their co-…
BackgroundExtracellular vesicles (EVs) are lipid-delimited particles that mediate intercellular communication and have been implicated in both autoimmune and prothrombotic conditions. Livedo reticularis (LR) is a cutaneous vascular pattern associated w…
BackgroundCentral lymph node metastasis in clinically node-negative papillary thyroid carcinoma is regulated by the tumor immune microenvironment, yet existing studies have addressed molecular, systemic immune, and local imaging signals in isolation wi…
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a remarkably broad and heterogeneous autoantigen repertoire. While epitope spreading, aberrant B-cell activation, and molecular mimicry act in concert with defective a…
BackgroundGlymphatic dysfunction has been reported in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), yet disease-specific patterns of glymphatic-related impairment and their structural and cognitive consequences remain poor…
