BackgroundFungal infections significantly compromise the prognosis of patients with interstitial pneumonia with autoimmune features (IPAF). However, the specific immune-related risk factors and their impact on clinical stability remain poorly defined. …
BackgroundIrritable bowel syndrome (IBS) is a prevalent disorder of gut–brain interaction increasingly linked to immune and inflammatory dysregulation. Whether IBS predisposes to systemic rheumatic diseases remains uncertain.MethodsWe conducted a retro…
Non-small cell lung cancer (NSCLC) is frequently associated with sarcopenia, a debilitating condition of muscle wasting driven by complex tumor–muscle cross-talk. To unravel the regulatory mechanisms underlying this phenotype, we reconstructed a compre…
Pediatric asthma is a highly heterogeneous inflammatory syndrome characterized by distinct immune endotypes. The inception of asthma predominantly occurs during the first 1,000 days of life, a critical window of immunological plasticity. Within this cr…
BackgroundFish allergy is a potentially severe condition that is frequently managed with broad elimination diets. Molecular allergology may improve risk stratification by distinguishing clinically relevant fish allergy from asymptomatic sensitization. …
The gut and liver form an anatomical and functional unit linked by the portal circulation, the biliary tract, lymphatic drainage, and neuroimmune pathways. In recent years, the classical gut-liver axis has expanded from a predominantly microbial and me…
Background and objectiveDermographism is a frequent clinical finding in patients with chronic spontaneous urticaria (CSU) and may reflect enhanced mast-cell reactivity, increased disease severity, and prolonged disease persistence. This study aimed to …
Autoimmune diseases (ADs) and related immune-mediated inflammatory disorders are characterized by loss of immune tolerance, persistent inflammatory activation, immune-cell imbalance, oxidative stress, and tissue-specific injury. Although conventional i…
BackgroundClear cell renal cell carcinoma (ccRCC) is metabolically primed for ferroptosis, yet the prognostic relevance and mechanistic contribution of ferroptosis-related genes remain incompletely defined. This study aimed to identify ferroptosis-asso…
Autoimmune thyroid diseases (AITDs), mainly Hashimoto’s thyroiditis and Graves’ disease, are common organ-specific autoimmune disorders driven by complex interactions among genetic susceptibility, immune dysregulation, environmental exposure, and micro…
