The current classification of porcine immunoglobulin G (IgG) subclasses relies on phylogenetic analysis of gene sequences, resulting in a nomenclature that is inapt to predict biological function. Here, we propose a revised, functionality-based nomencl…
BackgroundAcute leukemia (AL) is a malignant hematological disorder, with two main subtypes: acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The incidence rate of AML and ALL is estimated at approximately 2.7 and 1.5 per 100,000 pe…
Tumor immunity is increasingly understood not only through the cellular composition of the tumor microenvironment, but also through spatially organized local niches that can help determine where immune recognition is initiated, constrained, suppressed,…
BackgroundResponse to secukinumab in psoriasis varies over time and is not fully captured by single timepoint endpoints. Baseline features associated with long-term response trajectories remain unclear.ObjectiveTo identify 52-week secukinumab response …
BackgroundMixed-type IgA vasculitis (IgAV) is common in clinical practice, but its internal heterogeneity and prognostic significance, especially in renal involvement, remain unclear. This study aimed to characterize mixed-type IgAV, compare renal risk…
Sepsis-induced immunoparalysis is a dynamic state of acquired immune dysfunction characterized by impaired antigen presentation, lymphocyte exhaustion, defective innate immune responses, and increased susceptibility to secondary infection. Increasing e…
BackgroundAdjuvant treatment of melanoma patients with PD-1-based immunotherapy has improved recurrence rate, and became a standard treatment. However, a considerable proportion of patients recur within 1–2 years, necessitating the identification of pr…
ObjectivesANCA-associated vasculitis (AAV) presents with rapidly progressive glomerulonephritis, yet the tissue-level molecular landscape in pediatric AAV remains poorly understood. We aimed to characterize spatially resolved renal disease programs acr…
Growth differentiation factor 15 (GDF15) is a stress-responsive cytokine that has emerged as a pleiotropic regulator in skin biology, yet its context-dependent functions—ranging from protective to pathogenic—remain incompletely understood. This narrati…
