Lysophosphatidylcholines (LPCs) are among the most abundant circulating bioactive lipids, whose fatty acid compositions critically influence their immunomodulatory functions. Alterations in circulating LPC species have been implicated in inflammatory s…
BackgroundHenoch-Schönlein purpura nephritis (HSPN) is a common secondary glomerular disease in children. Approximately 30% of children with Henoch-Schönlein purpura develop this renal complication, and among them, about 20% may progress to chronic kid…
MOGAD is a rare autoimmune encephalomyelitis that shares similar clinical manifestations with other central nervous system demyelinating diseases. However, they must be distinguished due to their distinct pathogenesis and treatment methods. Currently, …
IntroductionCognitive impairment significantly impacts social function in Bipolar disorder (BD). This study explores the link between immune markers, white matter microstructure, and cognitive function in depressed BD patients enhance early diagnosis a…
The current classification of porcine immunoglobulin G (IgG) subclasses relies on phylogenetic analysis of gene sequences, resulting in a nomenclature that is inapt to predict biological function. Here, we propose a revised, functionality-based nomencl…
BackgroundAcute leukemia (AL) is a malignant hematological disorder, with two main subtypes: acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The incidence rate of AML and ALL is estimated at approximately 2.7 and 1.5 per 100,000 pe…
Tumor immunity is increasingly understood not only through the cellular composition of the tumor microenvironment, but also through spatially organized local niches that can help determine where immune recognition is initiated, constrained, suppressed,…
BackgroundResponse to secukinumab in psoriasis varies over time and is not fully captured by single timepoint endpoints. Baseline features associated with long-term response trajectories remain unclear.ObjectiveTo identify 52-week secukinumab response …
BackgroundMixed-type IgA vasculitis (IgAV) is common in clinical practice, but its internal heterogeneity and prognostic significance, especially in renal involvement, remain unclear. This study aimed to characterize mixed-type IgAV, compare renal risk…
