Frontiers in Immunology – Page 13

Immunomodulatory functions of growth differentiation factor 15 in skin aging and inflammatory dermatoses

31 de July de 2026 by Ruijun Wang

Growth differentiation factor 15 (GDF15) is a stress-responsive cytokine that has emerged as a pleiotropic regulator in skin biology, yet its context-dependent functions—ranging from protective to pathogenic—remain incompletely understood. This narrati…

Immune dysregulation and postoperative wound complications in systemic autoimmune rheumatic diseases: toward disease-specific risk stratification

31 de July de 2026 by Shiuan-Tzuen Su

Association of C-reactive protein-albumin-lymphocyte index and coronary artery calcification on major adverse cardiovascular events of dialysis patients with acute coronary syndrome

31 de July de 2026 by Congyi Cheng

Background and objectiveInflammation, immune dysfunction, malnutrition and severe coronary artery calcification (CAC) are critical cardiovascular risk factors in patients on dialysis. However, their combined prognostic value in dialysis patients with a…

Treatment prioritization of chemotherapy-anchored regimens after EGFR-TKI failure in EGFR-mutant NSCLC: a systematic review, pairwise meta-analysis and Bayesian network meta-analysis with probabilistic multi-criteria decision analysis

31 de July de 2026 by Yaoyao Jing

BackgroundIn advanced EGFR-mutant non–small cell lung cancer (NSCLC) after EGFR-TKI failure, chemotherapy alone offers limited benefit, while heterogeneous efficacy and safety across combination regimens complicate treatment selection. We systematicall…

TA-TMA occurring after sequential CD7 CAR-T cell therapy and allogeneic hematopoietic stem cell transplantation: a case report

31 de July de 2026 by Jinlin Zhang

Currently, CAR-T cell therapy bridging to allogeneic hematopoietic stem cell transplantation (allo-HSCT) has become a pivotal therapeutic strategy for refractory/relapsed hematologic malignancies. Sequential therapy with CD7 chimeric antigen receptor T…

CXCL1-CXCR2 axis inhibits melanogenesis through the suppression of the WNT/β-catenin pathway

31 de July de 2026 by Yushan Zhang

Abnormal skin pigmentation is a common clinical dermatological issue, and its occurrence and development are closely associated with the inflammatory microenvironment. However, the interactive regulatory mechanisms between inflammatory factors and mela…

Anti-CD123 CAR-T therapy combined with autologous SCT and venetoclax maintenance in refractory BPDCN ineligible for allogeneic transplantation: a case report and review of the literature

31 de July de 2026 by Fan Yang

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy with limited therapeutic options for patients ineligible for allogeneic hematopoietic stem cell transplantation (allo-HSCT). While CD123-targeted therapies and…

Identification of novel HLA class I-restricted hepatitis B virus peptides and their modulation by peptide editor TAPBPR

31 de July de 2026 by Ricky Sinharay

IntroductionHepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma and infections remain a substantial global health problem for which no curative therapy exists. As cytotoxic CD8+ T lymphocytes are the principal effectors of natural …

Development of a predictive tool for hemophagocytic lymphohistiocytosis/macrophage activation syndrome risk in adult-onset Still’s disease

31 de July de 2026 by Xinyue Hong

BackgroundHemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) is one of the most common complications of adult-onset Still’s disease (AOSD), and a leading cause of organ failure and mortality in these patients. Early diagnosis a…

Exploratory multi-omics analysis suggests context-dependent immune responses to vitamin D3 supplementation in PBMCs of multiple sclerosis patients

31 de July de 2026 by Tanya Tripathi

IntroductionVitamin D deficiency is a recognized risk factor for multiple sclerosis (MS), yet the in vivo molecular mechanisms linking vitamin D3 supplementation to immune regulation remain incompletely understood. MethodsWe performed longitudinal RNA …