BackgroundOsteoporosis is classically defined by reduced bone mass and microarchitectural deterioration, but osteoimmune dysregulation within the bone marrow microenvironment is increasingly recognized as an important contributor to bone loss. The RANK…
BackgroundAdenoid hypertrophy (AH) frequently coexists with allergic rhinitis (AR) in children, yet the molecular mechanisms underlying this comorbidity remain unclear. Using nasopharyngeal swab-based transcriptomics—enabling inclusion of healthy pedia…
Anti–John Cunningham virus (JCV) serological testing constitutes a cornerstone of progressive multifocal leukoencephalopathy (PML) risk assessment in patients receiving natalizumab for multiple sclerosis (MS). Existing PML risk stratification algorithm…
ObjectiveTo compare efficacy, survival and tumor immune microenvironment between neoadjuvant chemoradiotherapy (NCRT) and neoadjuvant immunochemotherapy (NICT) in patients with esophageal squamous cell carcinoma (ESCC) to guide individualized treatment…
Acute respiratory distress syndrome (ARDS) is a life-threatening condition with high mortality and limited effective pharmacotherapies. Accumulating evidence has established mitochondrial dysfunction as a central pathogenic hub in ARDS. Injured mitocho…
IntroductionSplenocytes are important for various applications in medicine and biotechnology, but isolation methods are often limited by low yield, poor viability, bias towards certain cell subtypes, and degradation of surface marker expression. Here, …
BackgroundImmune checkpoint inhibitor (ICI)–related overlap syndrome involving myositis, myocarditis, and myasthenia gravis (3M overlap syndrome) is rare but potentially fatal. Current evidence is derived mainly from case reports and small case series,…
IntroductionFibroblast activation protein (FAP)-targeted radiopharmaceuticals have been widely applied in oncologic imaging and therapy, while their application in pulmonary fibrosis remains underexplored. This study investigated the biodistribution an…
Chronic myeloid leukemia (CML) with megakaryoblastic blast crisis (MKBC) as the initial manifestation is extremely rare, accounting for less than 3% of all CML cases. Philadelphia chromosome-positive acute myeloid leukemia, FAB M7 subtype (Ph+ AML-M7),…
BackgroundDonor-derived cell-free DNA (dd-cfDNA) is a promising noninvasive marker of graft injury after lung transplantation (LTx), but its real-world value for identifying rejection-associated allograft injury and its interpretation across infection …
