Cancer remains a leading cause of mortality worldwide, with rising incidence and death rates continuing to rise. While conventional treatments such as surgery, radiotherapy, and chemotherapy form the backbone of cancer care, they are often limited by a…
BackgroundOsteoarthritis, a common degenerative osteochondral disease, has a close relationship between its mechanism of Macrophage polarization. However, there are relatively few relevant studies in this field, and a more mature research system has no…
ObjectivesThis meta-analysis evaluated the direction and strength of associations between air pollution, emerging chemical pollutants, and systemic lupus erythematosus (SLE) incidence, clarifying distinct relationships by pollutant type.MethodBy utiliz…
ObjectLiver fibrosis is a key stage in chronic liver disease, but targeted treatments are scarce. Pien Tze Huang (PZH), a traditional Chinese medicine, shows anti-fibrotic potential, though its mechanisms are not fully understood.MethodA liver fibrosis…
BackgroundBladder cancer is a significant malignancy, for which prognostic prediction and understanding of the tumor immune microenvironment are crucial. B cells play a key regulatory role in this environment, making their study essential for advancing…
BackgroundPrimary focal hyperhidrosis (PFH) significantly impacts patients’ physical and mental health, yet its underlying mechanisms remain unclear.MethodsThis study involved 80 healthy controls and 60 patients each with primary palmar (PPH), craniofa…
The gut microbiome critically regulates antitumor immunity through its metabolic byproducts, which serve as pivotal mediators of host-microbe crosstalk in tumor immunotherapy. This review synthesizes cutting-edge evidence on how microbial metabolites—i…
IntroductionImmune cells form defined pro- and anti-inflammatory regions around a pathogen during an innate immune response. These include, in Toll-like receptor (TLR)-2-induced inflammation, a core region containing the pathogen, an adjacent pro-infla…
