ObjectiveThis study aimed to assess the long-term results of the watch-and-wait (W&W) strategy in patients with clinical stage II/III mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H) colorectal cancer (CRC) who received neoa…
Extracellular vesicles (EVs) are membrane-bound particles secreted by diverse cell types and mediate intercellular communication through the transfer of proteins, RNAs, lipids, metabolites and other biomolecules. EVs participate in multiple physiologic…
IntroductionChronic rejection remains a major barrier to long-term survival after renal transplantation. However, our understanding of the transcriptional programs and metabolic alterations that shape the functions of human kidney cell populations duri…
Antibody-mediated rejection (AMR) is the primary immunological obstacle limiting long-term survival in heart transplant recipients. Driven by donor-specific antibodies (DSA), AMR damages graft microvasculature through multiple pathways, including compl…
Pigs are attracting increasing attention as a large-animal model with translational relevance in biomedical research. They share several immunological similarities with humans, although the pig immune system has not been fully characterized yet, also a…
BackgroundFungal infections significantly compromise the prognosis of patients with interstitial pneumonia with autoimmune features (IPAF). However, the specific immune-related risk factors and their impact on clinical stability remain poorly defined. …
Natural killer (NK) cells are important effector cells of the innate immune system and have been investigated as a therapeutic platform for cancer immunotherapy. Although NK cell-based therapies have shown clinical activity in hematological malignancie…
The repetition of a condition following endoscopic sinus surgery (ESS) poses an important difficulty in type 2 chronic rhinosinusitis with nasal polyps (CRSwNP) therapy. The recurrent nature of the disease is probably linked to the dynamic interplay of…
BackgroundIrritable bowel syndrome (IBS) is a prevalent disorder of gut–brain interaction increasingly linked to immune and inflammatory dysregulation. Whether IBS predisposes to systemic rheumatic diseases remains uncertain.MethodsWe conducted a retro…
