Cellular & Molecular Immunology, Published online: 29 July 2026; doi:10.1038/s41423-026-01453-4NLRC3 enhances antitumor immunity by specifically negatively regulating M-MDSCs in a STING-dependent manner
J Leukoc Biol. 2026 Jul 3;118(7):qiag101. doi: 10.1093/jleuko/qiag101. NO ABSTRACT PMID:42520763 | DOI:10.1093/jleuko/qiag101
BackgroundThe efficacy of cellular therapies has been demonstrated in hematologic malignancies, and their use is expanding to solid tumors. Predictors of outcomes and toxicities remain limited in patients undergoing cellular therapies for solid tumors….
IntroductionNon-small cell lung cancer (NSCLC) remains one of the leading causes of cancer-related death, with most patients diagnosed at advanced, unresectable stages. Although immune-checkpoint inhibitors have transformed the therapeutic landscape, o…
Atopic dermatitis is a chronic inflammatory skin disease influenced by genetic predisposition, immune dysregulation, and environmental factors, as well as skin and gut microbiota. This review summarises the key mechanisms involved in this disease devel…
BackgroundIntrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with poor prognosis and limited treatment options. Disulfidptosis, a novel cell death pathway driven by disulfide bond accumulation, has emerged as a potential mechanism in can…
Oral squamous cell carcinoma (OSCC) is an aggressive malignancy with a profoundly immunosuppressive tumor microenvironment and persistently poor responses to immune checkpoint inhibitors. Recent evidence highlights dysregulated iron metabolism as a cri…
BackgroundChronic spontaneous urticaria (CSU) is a heterogeneous immune-mediated disorder characterized by recurrent wheals and/or angioedema. Despite advances in understanding its pathogenesis, robust biomarkers for disease stratification remain lacki…
Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation accompanied by pathological angiogenesis, which contributes to pannus formation and disease progression. However, the upstream mechanisms regulating pathological angiogenesis i…
BackgroundAdenoid hypertrophy (AH) frequently coexists with allergic rhinitis (AR) in children, yet the molecular mechanisms underlying this comorbidity remain unclear. Using nasopharyngeal swab-based transcriptomics—enabling inclusion of healthy pedia…
