ObjectiveTo compare efficacy, survival and tumor immune microenvironment between neoadjuvant chemoradiotherapy (NCRT) and neoadjuvant immunochemotherapy (NICT) in patients with esophageal squamous cell carcinoma (ESCC) to guide individualized treatment…
IntroductionSplenocytes are important for various applications in medicine and biotechnology, but isolation methods are often limited by low yield, poor viability, bias towards certain cell subtypes, and degradation of surface marker expression. Here, …
BackgroundImmune checkpoint inhibitor (ICI)–related overlap syndrome involving myositis, myocarditis, and myasthenia gravis (3M overlap syndrome) is rare but potentially fatal. Current evidence is derived mainly from case reports and small case series,…
IntroductionFibroblast activation protein (FAP)-targeted radiopharmaceuticals have been widely applied in oncologic imaging and therapy, while their application in pulmonary fibrosis remains underexplored. This study investigated the biodistribution an…
Chronic myeloid leukemia (CML) with megakaryoblastic blast crisis (MKBC) as the initial manifestation is extremely rare, accounting for less than 3% of all CML cases. Philadelphia chromosome-positive acute myeloid leukemia, FAB M7 subtype (Ph+ AML-M7),…
BackgroundDonor-derived cell-free DNA (dd-cfDNA) is a promising noninvasive marker of graft injury after lung transplantation (LTx), but its real-world value for identifying rejection-associated allograft injury and its interpretation across infection …
BackgroundImmunoglobulin G (IgG) subclasses have been documented to have a close association with pemphigus. Nevertheless, the relationship among IgG subclasses, anti-desmoglein (anti-Dsg) autoantibodies, and disease activity remains ambiguous, and the…
BackgroundFocal segmental glomerulosclerosis (FSGS) is a heterogeneous glomerular disease frequently treated with high-dose glucocorticoids and calcineurin inhibitors, which can markedly increase susceptibility to opportunistic infections.Case presenta…
BackgroundTargeted-release budesonide (Nefecon) has demonstrated efficacy in randomized trials for IgA nephropathy (IgAN), yet direct comparative real-world evidence against systemic corticosteroids is scarce, limiting clinical decision-making.MethodsW…
Complement factor H (FH), encoded by CFH, is a principal soluble regulator of the alternative complement pathway, but its roles in cancer extend beyond extracellular complement control. Intracellular FH has been linked to p53/NF-κB signaling, cell-cycl…
