BCL11B is a transcription factor with six C2H2-type zinc-finger domains. Studies in mice have shown that Bcl11b plays essential roles in T cell development. Several germline heterozygous BCL11B variants have been identified in human patients with inbor…
Aberrant glycosylation patterns of glycoproteins and glycolipids have long been recognized as one the major hallmarks of cancer cells that has led to numerous glycoconjugate vaccine attempts. These abnormal glycosylation profiles mostly originate from …
BackgroundImmune checkpoint therapy, involving the programmed cell death 1 (PD-1) monoclonal antibody, has revolutionized the treatment of cancer. Tertiary lymphatic structure (TLS) serves as an immune indicator to predict the efficacy of PD-1 antibody…
Nature Reviews Immunology, Published online: 29 February 2024; doi:10.1038/s41577-024-01015-7Plasma cells use P2RX4 to sense the regulated release of ATP from osteoblasts and this protects against ER stress-driven apoptosis.
How cells induce the production of antiviral molecules while shutting down protein translation to limit viral replication remains unclear. Here, Harioudh et al. show a non-canonical function for the interferon-induced antiviral protein, OAS1, which seq…
Cellular & Molecular Immunology, Published online: 27 February 2024; doi:10.1038/s41423-024-01134-0Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling
Our understanding of how metabolites in the tumor microenvironment impact tumor-intrinsic immune responses remains incomplete. Here, Ding et al. reveal that lactate triggers RNA-splicing-mediated CTLA-4 expression in tumor-infiltrating Treg cells, whic…
Nature Reviews Immunology, Published online: 27 February 2024; doi:10.1038/s41577-024-01011-xIn this Tools of the Trade article, Giulia Adriani and Andrea Pavesi describe a new microfluidic device that supports the generation of vascul…
Cellular & Molecular Immunology, Published online: 26 February 2024; doi:10.1038/s41423-024-01137-xNLRP3 inflammasome activation and NETosis positively regulate each other and exacerbate proinflammatory responses: implications of N…
Cellular & Molecular Immunology, Published online: 26 February 2024; doi:10.1038/s41423-024-01143-zComing of age: the formation and function of age-associated B cells
