IntroductionThe heterogeneity of outcomes after Mycobacterium tuberculosis (Mtb) exposure is a conundrum associated with millennia of host-pathogen co-evolution. We hypothesized that human myeloid cells contain genetically encoded, Mtb-specific respons…
Salmonid alphavirus (SAV) causes pancreas disease (PD), which negatively impacts farmed Atlantic salmon. In this study, fish were vaccinated with a DNA-PD vaccine (DNA-PD) and an oil-adjuvanted, inactivated whole virus PD vaccine (Oil-PD). Controls wer…
BackgroundThe neurodegenerative processes leading to glaucoma are complex. In addition to elevated intraocular pressure (IOP), an involvement of immunological mechanisms is most likely. In the new multifactorial glaucoma model, a combination of high IO…
IntroductionThe antigen-presenting cell function of insulin-reactive B cells promotes type 1 diabetes (T1D) in non-obese diabetic (NOD) mice by stimulating pathogenic T cells leading to destruction of insulin-producing β-cells of pancreatic islets.Meth…
Cellular & Molecular Immunology, Published online: 06 March 2024; doi:10.1038/s41423-024-01142-0Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2
Nature Reviews Immunology, Published online: 06 March 2024; doi:10.1038/s41577-024-01017-5Author Correction: Clonal haematopoieis-associated, age-related motor deficits caused by monocyte-derived microglia
Nature Reviews Immunology, Published online: 06 March 2024; doi:10.1038/s41577-024-01013-9A preprint by Zhou et al. shows that the clinical efficacy of immune checkpoint blockade in patients with cancer does not depend on the presence …
Background
Patients with paraneoplastic syndromes (PNS) are excluded from clinical trials involving immune checkpoint inhibitors (ICIs) due to safety concerns. Moreover, real-world data on efficacy and safety is scarce.
Methods
In this retrospective …
