Publicaciones – Page 1956

Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase

1 de March de 20241 de March de 2024 by

Influenza neuraminidase (NA) is underappreciated as a vaccine target owing to its incomplete epitope landscape. Lederhofer et al. isolated human monoclonal antibodies to NA underside (i.e., dark side) epitopes with broad cross-reactivity across N2 subt…

The transcription factor NF-κB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling

1 de March de 20241 de March de 2024 by

Innate immune cells tailor responses to specific stimuli via the selective activation of hundreds of genes. Feng et al. examine inducible nucleosome remodeling in response to TLR4 stimulation and reveal a unique requirement for NF-κB. Collaboration bet…

Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer

3 de March de 20241 de March de 2024 by Zhou, Y., Zhang, W., Wang, B., Wang, P., Li, D., Cao, T., Zhang, D., Han, H., Bai, M., Wang, X., Zhao, X., Lu, Y.

Background
The effectiveness of immune checkpoint inhibitors in colorectal cancer (CRC) is limited due to the low tumor neoantigen load and low immune infiltration in most microsatellite-stable (MSS) tumors. This study aimed to develop a mitochondria-…