Immune checkpoint blockade (ICB) therapy has dramatically improved the survival outcomes of patients with locally advanced unresectable and metastatic non-small cell lung cancer (NSCLC). In particular, accumulated clinical trials and systematic reviews…
Metabolic disorders, such as obesity, diabetes mellitus, metabolic dysfunction-associated steatotic liver disease, and atherosclerosis, collectively pose a severe global public health crisis. Systemic chronic low-grade inflammation caused by metabolic …
IntroductionOvarian cancer (OC) is the most lethal gynecological malignancy. A deeper insight into tumor microenvironment (TME) interactions is essential for developing novel therapeutic approaches. leukocyte immunoglobulin-like receptor B4 (LILRB4) is…
ObjectivesTo develop and validate a pretreatment computed tomography (CT)-derived model for predicting major pathological response (MPR) to neoadjuvant immunochemotherapy in resectable non-small-cell lung cancer (NSCLC).MethodsThis multicenter retrospe…
Cancer progression and therapeutic response remain highly variable across tumor types and are not fully explained by tumor-intrinsic alterations alone. The human microbiome has emerged as a systems-level regulator of cancer biology, integrating signals…
BackgroundOral stromal and epithelial cells contribute to mucosal inflammation through cytokine-induced chemokine production. Essential oil-containing mouth rinses are widely used as adjuncts to oral hygiene, but whether zinc-containing formulations di…
BackgroundLatent autoimmune diabetes in adults (LADA) is characterized by progressive β-cell impairment and severe glycemic lability, predisposing patients to in-hospital hypoglycemia. Few tailored risk-stratification models exist for this population. …
Autoimmune thyroid diseases (AITDs), including Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), affect approximately 2–5% of the global population. They are the most common organ-specific autoimmune disorders worldwide. Growing epidemiological an…
ObjectiveThe diagnosis of Kikuchi–Fujimoto disease (KFD) is challenging, which is mainly based on typical histopathological findings from a lymph node biopsy. We aimed to develop and validate a predictive model for the diagnosis of KFD based on cytokin…
BackgroundHemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome that can obscure underlying malignancies, particularly aggressive B-cell lymphoma. Severe cytopenias and coagulopathy often preclude conventional biopsy…
