Sjögren’s syndrome (SjS) is a systemic, highly diverse, and chronic autoimmune disease with a significant global prevalence. It is a complex condition that requires careful management and monitoring. Recent research indicates that epigenetic mechanisms…
BackgroundGlioblastoma (GBM), with its high recurrence and mortality rates, makes it the deadliest neurological malignancy. Oxidative phosphorylation is a highly active cellular pathway in GBM, and NFYB is a tumor-associated transcription factor. Both …
Rheumatoid arthritis (RA) is a systemic autoimmune disorder characterized by swollen joints, discomfort, stiffness, osteoporosis, and reduced functionality. Genetics, smoking, dust inhalation, high BMI, and hormonal and gut microbiota dysbiosis are all…
Plasma cells show remarkable longevity in vivo with broad heterogeneity between cells. By developing a minimal mathematical framework, Simons and Karin argue that the longevity and heterogeneity of plasma cell lifespan arise through the fine-tuning of …
The physiological importance of two alternative differentiation pathways for adult megakaryopoiesis is unclear. Li et al. show that megakaryocytes derived from different differentiation pathways have distinct activities and contribute to different phys…
Cellular & Molecular Immunology, Published online: 05 March 2024; doi:10.1038/s41423-024-01145-xDevelopment of NK cell-based cancer immunotherapies through receptor engineering
Cellular & Molecular Immunology, Published online: 05 March 2024; doi:10.1038/s41423-024-01144-ygp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity
Background
Over 50% of patients with relapsed or refractory large B-cell lymphoma (r/r LBCL) receiving CD19-targeted chimeric antigen receptor (CAR19) T-cell therapy fail to achieve durable remission. Early identification of relapse or progression rem…
ObjectiveThe occurrence of immune-mediated diseases (IMDs) in amyotrophic lateral sclerosis (ALS) patients is widely reported. However, whether IMDs and ALS is a simple coexistence or if there exists causal relationships between the two has been a subj…
