BackgroundProgressive pulmonary fibrosis (PPF) is a major cause of poor prognosis in connective tissue disease-associated interstitial lung disease (CTD-ILD). This study aims to analyze and evaluate the incidence of PPF and related influencing factors …
BackgroundAlthough the existence of antiphospholipid antibodies (aPL) has been extensively documented as a risk factor for thrombocytopenia, hemolytic anemia, and recurrent miscarriage, their contribution to renal damage in the context of the systemic …
BackgroundImmunotherapy has revolutionized the therapeutic paradigm for lung cancer, yet its clinical efficacy exhibits significant interpatient heterogeneity. The implementation of personalized immunotherapy critically depends on the precise identific…
BackgroundVascularized composite allotransplantation (VCA) offers unique reconstructive solutions for severe tissue loss, restoring form and function. Acute and chronic rejection remains a significant barrier, with acute episodes occurring in most reci…
ObjectiveTo assess platelet-to-lymphocyte ratio (PLR) prognostic utility for overall (OS) and progression-free survival (PFS) in immune checkpoint inhibitor-treated cancer patients, and examine impacts of geography, cancer type, cutoff, ICI class, trea…
IntroductionWe conducted an etiology-stratified network meta-analysis of first-line systemic therapies for advanced HCC to compare newer regimens beyond sorafenib-based RCT evidence (HBV, HCV, or non-viral).MethodsFollowing PRISMA-NMA, we searched PubM…
BackgroundPembrolizumab-induced immune-related oral mucositis (irOM) is a rare and often underrecognized toxicity. This study aimed to systematically characterize its clinical profile, histopathologic patterns, management strategies, and outcomes to su…
This manuscript reviews the current evidence describing the relationships between surgical trauma, altered intestinal permeability, dysbiosis, inflammasome activation, and postoperative inflammation in the development of AL. Surgical tissue disruption …
IntroductionMedication-overuse headache (MOH) develops when drugs intended for acute pain relief lower the threshold for headache chronification. The biological mechanisms driving this transition remain poorly understood. We aim to synthesize current e…
BackgroundVascularized composite allotransplantation (VCA) joins skin, muscle, bone, nerve, and vessels into a single graft that is both highly immunogenic and mechanically complex. Biopolymers, natural or synthetic, can provide structural scaffolding,…
