BackgroundWhile immune checkpoint inhibitors (ICIs) have revolutionized first-line treatment for advanced gastric and gastroesophageal junction (GEJ) adenocarcinoma, outcomes across phase III trials remained heterogeneous. This study aimed to determine…
BackgroundKrabbe disease is a rare, rapidly progressive leukodystrophy with high early mortality. Hematopoietic stem cell transplantation (HSCT) is the main disease-modifying intervention used in clinical practice and may act through donor-derived myel…
BackgroundIL-17 pathway inhibitors are established treatments for active psoriatic arthritis (PsA), but comparative evidence within this therapeutic class remains limited. We compared the efficacy, safety, treatment rankings, and certainty of evidence …
ObjectiveB7-H3-targeted antibody-drug conjugates (B7-H3-targeted ADCs) have shown promising antitumor effects in patients with previously treated small cell lung cancer (SCLC), yet the available evidence on their efficacy and safety has not been system…
IntroductionMetabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous liver disease involving metabolic dysfunction, inflammatory activity, immune activation, and fibrotic remodeling. Immune-inflammatory biomarkers and immune-…
ObjectiveTo compare the efficacy and safety of IL-23 p19 monoclonal antibodies for moderate-to-severe plaque psoriasis.MethodsPubMed, Embase, Web of Science, and the Cochrane Library were searched from inception to 21 February 2026. We included randomi…
BackgroundNeoadjuvant immune checkpoint inhibitors combined with chemotherapy improve pathological complete response in early-stage triple-negative breast cancer, but the consistency of benefit, role of PD-L1 expression, and immune-related toxicity rem…
BackgroundHematologic neoplasms remain a growing global burden, with relapse, resistance, and limited treatment options persisting. Bispecific antibodies (BsAbs) offer a novel multi-antigen targeting strategy. This systematic review assesses their effi…
BackgroundCeliac disease (CeD) is a chronic gluten-triggered immune-mediated enteropathy. Increasing evidence suggests that the gut microbiota may contribute to CeD pathophysiology. However, the global research landscape, hotspot evolution, and immune-…
IntroductionEnvironmental exposures have been hypothesised to influence immune tolerance, but human studies of autoimmune inflammatory rheumatic diseases (AIRDs) often report exposure–disease associations without measuring immune intermediates. We mapp…
