BackgroundSTAR0602 is a selective bifunctional T cell agonist targeting Vβ6/Vβ10 T-cell receptors fused to interleukin-2, with emerging clinical activity in anti-PDL1–resistant tumors. Its murine surrogate, mSTAR1302, expands Vβ13 T cells and mediates …
BackgroundProstate cancer is one of the most common malignant tumors of the male genitourinary system. The impaired activity of natural killer (NK) cells observed in prostate cancer may contribute to immune evasion. This study aimed to develop robust N…
In recent years, rates of maternal obesity before conception have continued to rise globally. Maternal obesity in early pregnancy may alter intrauterine immune mechanisms, impact fetal metabolic programming, and increase the risk of later-life obesity….
Immune-related cystitis is an uncommon immune-related adverse event (irAE) linked to immune checkpoint inhibitors (ICIs), and managing cases refractory to corticosteroids remains clinically challenging due to the lack of standardized treatment guidelin…
The repair process following spinal cord injury (SCI) involves intricate crosstalk between neuroimmune and vascular systems, with microglia-vascular interactions increasingly recognized as an important regulatory interface that may shape both secondary…
Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that arise in non-lymphoid tissues under chronic inflammatory conditions and during tumor development. Although TLS have often been associated with a favorable prognosis and enhanced th…
IL-17, a pleiotropic cytokine, activates downstream signaling pathways through the IL-17 receptor (IL-17R), influencing the expression and regulation of inflammatory mediators, growth factors, and matrix metalloproteinases, thereby modulating various b…
Depression and breast cancer are two major health concerns in the medical field today. Not only do they mutually influence the risk of onset and disease progression, but they also collectively lead to poorer clinical outcomes and reduced quality of lif…
Exosomes are extracellular vesicles (EVs) with a lipid bilayer structure, ranging from 30 to 150 nm in diameter, that are secreted by cells. As key carriers of biological information, they play pivotal roles in diverse physiological and pathological pr…
Systemic lupus erythematosus (SLE) is a chronic, complex autoimmune disease arising from the interaction of environmental triggers with a genetically susceptible host. Among environmental factors, infection with Epstein–Barr virus (EBV) has one of the …
