Frontiers in Immunology
Follicular T cells in the ovarian cancer immune microenvironment: biological insights and translational implications
BackgroundOvarian cancer, particularly high-grade serous ovarian cancer (HGSOC), exhibits a generally poor response to immune checkpoint inhibitors, and its underlying mechanisms remain incompletely defined. This observation suggests that an immunologi…
Extracellular vesicle signalling in perioperative neurocognitive disorders
Perioperative neurocognitive disorders (PND), including postoperative delirium, delayed neurocognitive recovery, and postoperative neurocognitive disorder, are important complications in older and vulnerable surgical patients. These conditions are asso…
BCL-XL drives fibrotic and leukemic progression in myeloproliferative neoplasms
BackgroundMyeloproliferative neoplasms (MPNs) are frequently accompanied by bone marrow fibrosis and leukemic transformation, yet the cellular and molecular mechanisms that sustain apoptosis resistance and fibrotic progression remain unclear.MethodsBon…
Swimming ameliorates intervertebral disc degeneration accompanied by Rpl23a downregulation and changes in its immune-inflammatory pathway
BackgroundIntervertebral disc degeneration (IVDD) is characterized by persistent inflammation and extracellular matrix degradation, but the driving mechanism of immune dysregulation in the intervertebral disc remains unclear. Ribosomal protein L23a (Rp…
Predicting response to immunochemotherapy in EGFR-mutant lung adenocarcinoma after third-generation TKI resistance using CT radiomics-based habitat imaging
BackgroundThird-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) resistance poses a significant therapeutic challenge in advanced lung adenocarcinoma. This study aimed to develop and validate a computed tomography (CT)…
Codonopsis pilosula polysaccharide attenuates the inflammatory response in macrophages induced by Brucella abortus outer membrane protein 19 via regulating ATP2A1 to modulate cell adhesion and calcium signaling
Brucellosis is a zoonotic disease caused by Brucella species. Its pathogenesis is closely associated with bacterial evasion of macrophage-mediated killing, induction of a pro-inflammatory cytokine storm, and immune-mediated pathological damage. Accumul…
Development of a GMMA-based candidate vaccine against invasive nontyphoidal Salmonella disease
IntroductionInvasive nontyphoidal Salmonella (iNTS) disease is one of the most common causes of bacteremia in sub-Saharan Africa (sSA), mostly affecting children less than 5 years of age and with an associated 14.7% case fatality ratio. This disease is…
ILC imbalance – a new piece in the gut-kidney axis puzzle
BackgroundThe progression of chronic kidney disease (CKD) is closely linked to gut microbiota dysbiosis and the consequent accumulation of harmful microbial metabolites, forming a vicious cycle called “gut-kidney axis.” However, the specific immune mec…
Gene expression profiling of dendritic cell tolerance dysfunction in women with systemic lupus erythematosus
BackgroundDendritic cells (DCs) are central regulators of immune tolerance, and disturbances in their phenotype and function contribute to the breakdown of self-tolerance in systemic lupus erythematosus (SLE). Tolerogenic DCs (tolDCs), which suppress a…