BackgroundThis study evaluated the feasibility of dual-energy CT (DECT) for assessing the correlation between hydroxyproline (HYP) levels in lung tissue of patients with nonspecific interstitial pneumonia (NSIP) and lung volume and pulmonary function.M…
Interleukin-10 (IL-10) is classically defined as a potent anti-inflammatory cytokine that protects tissues by constraining myeloid activation and limiting inflammatory cytokine production. Yet, accumulating evidence indicates that, in defined contexts,…
BackgroundPatients with unresectable stage IIIB/C-IV non-squamous non-small cell lung cancer (NSCLC) lacking driver mutations (EGFR/ALK/ROS1/RET/BRAF/MET) face limited treatment options. This single-center prospective exploratory pilot case series, lim…
Chronic upper and lower airway inflammatory diseases (such as allergic rhinitis, chronic rhinosinusitis, and bronchial asthma) are a group of highly heterogeneous disorders primarily characterized by immune imbalance and persistent inflammation as thei…
Chronic lymphocytic leukemia (CLL) predominantly affects older adults; however, approximately 10% of patients are diagnosed at a younger age. Although overall survival appears comparable across age groups, emerging evidence suggests that early-onset CL…
Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), is a group of chronic gastrointestinal inflammatory diseases characterized by persistent mucosal inflammation and intestinal immune barrier dysfunction. …
BackgroundThe optimal choice of chemotherapy regimen for resectable colorectal liver metastases (CRLM) is still undetermined. The study aimed to estimate the impact of perioperative or adjuvant chemotherapy on disease-free survival (DFS), and explore t…
Periodontitis is a chronic inflammatory disease driven by dysregulated host–microbial interactions and failure of endogenous inflammation resolution, leading to progressive destruction of periodontal tissues. Increasing evidence indicates that inflamma…
ObjectiveChronic pancreatitis (CP) creates an inflammatory pancreatic microenvironment and is an established risk factor for pancreatic cancer (PC). However, immune-inflammatory links between CP and PC remain unclear. Isorhamnetin (ISO), a natural flav…
Osteoarthritis (OA) is one of the most common degenerative joint diseases, and its initiation and progression are closely associated with the inflammatory microenvironment within the joint. As key effector cells of innate immunity in the joint, macroph…
